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BioResearch

Image: This schematic illustration shows the working principle of the gold nanocage-based, photo-activated anti-bacterial drug delivery system (Photo courtesy of the University of Arkansas).

Bifunctional Gold Nanoparticles Destroy Bacterial Pathogens with Antibiotic and Thermal Killing

A team of bioengineers has designed a novel class of targeted bifunctional nanoparticles that attacks pathogenic bacteria with both antibiotic and photo-activated thermal killing strokes.  More...
12 Apr 2016
Image: Using reporter nanoparticles loaded with either a chemotherapy or immunotherapy, researchers could distinguish between drug-sensitive and drug-resistant tumors in a pre-clinical model of prostate cancer (Photo courtesy of Dr. Ashish Kulkarni, Brigham and Women\'s Hospital).

Bifunctional Anticancer Nanoparticles Deliver a Drug and Then Report Whether It Works

A novel nanoparticle-based transport system not only delivers an anticancer agent to a tumor, it reports whether the treatment is working.  More...
11 Apr 2016
Image: Pancreatic islets, shown as the lighter tissue among the darker, acinar pancreatic tissue in this hemalum-eosin stained slide (Photo courtesy of Wikimedia Commons).

Age-Related Epigenetic Changes May Lead to Development of Diabetes in Later Life

Epigenetic changes that cause increased methylation and partial or complete inactivation of genes during aging may contribute to the development of type II diabetes in older individuals.  More...
11 Apr 2016
Image: A study shows that a hollowed-out version of Cowpea mosaic virus could be useful in human therapies (Photo courtesy of the Scripps Research Institute).

New X-Ray Crystallography Study Confirms Structure of Empty Cowpea mosaic virus Particles

An X-ray crystallography study confirmed that empty Cowpea mosaic virus particles were structurally similar to the intact virus and showed that they could be used for drug transport and other biomedical applications.  More...
10 Apr 2016
Image: Ball-and-spoke three-dimensional model image of the anticancer drug romidepsin (Photo courtesy of Wikimedia Commons).

Combined Histone Deacetylase Inhibitor and Immunotherapy Shows Promise in Lung Cancer Mouse Models

A recent paper discussed how HDAC (histone deacetylase) inhibitors enhanced chemokine expression by T-cells and improved response to PD-1 immunotherapy in lung cancer.  More...
10 Apr 2016
Image: A small library of abietane-type diterpenoids amides was prepared from the plant-based dehydroabietylamine (left (1)) as a starting material, and the compounds evaluated for activity against Leishmania donovani and Trypanosoma cruzi. One compound (right (10)), an amide built from dehydroabietylamine and acrylic acid, was found to be highly effective against both parasites (Photo courtesy of Pirttimaa M et al., 2016, Journal of Natural Products).

Newly Developed Drug Demonstrates Potent, Selective Activity Against Trypanosomatid Parasites

Using a plant-based compound, scientists have developed a semi-synthetic drug that, upon testing on infected mammalian cells in culture, showed highly effective activity against two parasites from the trypanosomatid family: Leishmania donovani, a cause of visceral leishmaniasis, and Trypanosoma cruzi, cause of Chagas disease.  More...
06 Apr 2016
Image: Using E. coli bacteria as the initial organism for development, bioengineers have devised a programming language that simplifies the process of designing and incorporating synthetic gene elements to provide living cells with new functions (Photo courtesy of Janet Iwasa and MIT).

Programming Language Simplifies Design of Biological Circuits

Bioengineers have created a programming language that allows to rapidly design complex DNA-encoded circuits that provide new functions to living cells. In a first application, genetic circuits generated on plasmids expressed in Escherichia coli bacteria successfully regulated cellular functions in response to multiple environmental signals.  More...
05 Apr 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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