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BioResearch

Image: Genetic variants in the GATA4 gene have been implicated in bicuspid aortic valve development (Photo courtesy of the University of Michigan).

Gene Variants Implicated in Bicuspid Aortic Valve Development

Results presented in a recently published paper identified genetic variants associated with the formation of bicuspid aortic valve (BAV), a common congenital heart defect. More...
06 Jun 2017
Image: The Leica DMi8 S imaging system (Photo courtesy of Leica Microsystems).

New System Enables Multi-Color Resolution in Cells

A powerful microscope imaging system provides five times more speed and an increased viewing area up to 10,000 times, which can be combined with a new photomanipulation scanner to activate, ablate, and bleach cells or molecules within one experiment. More...
05 Jun 2017
Image: In cancer, cells divide uncontrollably and invade surrounding tissues. By removing a specific protein from cells, researchers were able to slow the cell cycle (Photo courtesy of the University of Rochester Medical Center).

Protein Slows Cancer with Cell Cycle Interference

A team of molecular biologists has identified a pathway that mediates mature microRNA (miRNA) decay - a process of undoing gene silencing that is less well understood than the processes that mediate miRNA biosynthesis. More...
05 Jun 2017
Image: A photomicrograph showing different cell types in the normal mammary ducts of a mouse. The luminal cells (red) are milk-producing cells and the basal cells (green) have contractile functions, but also are responsible for regenerating the mammary gland, as they contain the majority of mammary gland stem cells. These stem cells, located in the outer layer of the gland, are exposed to microenvironmental factors and interact with various immune cells, including macrophages, in the mammary gland (Photo courtesy of Toni Celià-Terrassa and Yibin Kang, Princeton University).

MicroRNA Maintains Cancer Cell Traits and Prompts Tumor Formation

A team of molecular biologists has determined that the microRNA mi-R-199a plays a critical role in breast tumor formation by helping to maintain the stem cell character of cancer stem cells and prevent them from differentiating into non-dividing cell types. More...
01 Jun 2017
Image: A micrograph showing inflammation of the large bowel in a case of inflammatory bowel disease (Photo courtesy of Wikimedia Commons).

MicroRNA Regulates Immune Response in Intestinal Inflammation

Results presented in a recently published paper revealed a previously unappreciated role for a specific microRNA in regulating the innate immune response during intestinal inflammation. More...
31 May 2017
Image: An innovative ELISA kit can identify diabetes patients at higher risk of developing lethal cardiovascular disease or renal failure (Photo courtesy of MyGenetx).

Haptoglobin Genotyping Enables Key Diabetes Treatment

A breakthrough ELISA kit, based on the Haptoglobin 2-2 (Hp 2-2) protein marker, can identify diabetes patients at higher risk of developing lethal cardiovascular disease or renal failure, thereby enabling them to take Vitamin E, a nutritional supplement shown to be of great benefit to them but posing harm to the remaining non HP 2-2 diabetic population. A CE mark application for the test is currently in progress, with FDA certification planned for the US market. More...
30 May 2017
Image: The structure of the human SIRT6 protein (Photo courtesy of the Protein Data Bank).

Levels of SIRT6 Linked to Neurodegenerative Disease

Low levels of the protein SIRT6 (Sirtuin-6) have been linked to aging-like changes in cells including the hyperphosphorylation of Tau, a critical marker in several neurodegenerative diseases such as Alzheimer's. More...
30 May 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.

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