We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Glass Filters to Separate Tumor Cells in Blood Tests Can Speed Up Cancer Diagnosis

By LabMedica International staff writers
Posted on 04 May 2023
Print article
Image: The experimental setup to capture CTCs and CAFs (Photo courtesy of Scientific Reports)
Image: The experimental setup to capture CTCs and CAFs (Photo courtesy of Scientific Reports)

Early diagnosis is crucial for effective cancer treatment, as even brief delays can impact patient health and longevity. One promising approach involves detecting circulating tumor cells (CTCs) and cancer-associated fibroblasts (CAFs) released by tumors into blood samples. Analyzing these cells can provide direct information about cancer and predict disease progression in its early stages. However, the number of CTCs in cancer patients' blood is extremely low, necessitating improvements in capture and culture efficiency. Although glass is commonly used for cell culturing in laboratories, its application in CTC culturing has been underexplored. Researchers have now identified the optimal dimensions of glass filters for capturing CTCs and CAFs, demonstrating their ability to detect cells from lung cancer patients.

Researchers from Nagoya University (Nagoya, Japan) employed a unique method to visualize and capture cells on glass filters, which could lead to more efficient tumor cell culturing and improved cancer detection. They developed glass filters with various shapes and dimensions to determine which best captured CTCs and CAFs from lung cancer patients. Additionally, they created a system called FROG-CHIP to visualize the CTCs and CAFs captured on the glass filters. The researchers discovered that the most effective patterns for capturing CTCs, while allowing white blood cells to pass through, consisted of a circular pattern with a pitch of 20 micrometers and a diameter of eight micrometers. These dimensions provided high capture efficiency without retaining a significant number of white blood cells.

"These results suggest that our glass filters are useful as a tool for the early diagnosis of tumors," said Professor Tanaka of the Center for Low-Temperature Plasma Sciences. "Our findings would be useful at hospitals, clinics, and diagnostic testing companies to speed up cancer diagnosis."

Related Links:
Nagoya University

Unit-Dose Twist-Tip BFS
Gold Supplier
Dengue ELISA Test
Dengue Virus IgM
Silver Supplier
HSV1+2 / VZV Test
Savvygen HSV1+2 / VZV
Semi-Automatic Biochemistry Analyzer

Print article


Clinical Chem.

view channel
Image: Electrochemical cells etched by laser on wooden tongue depressor measure glucose and nitrite in saliva (Photo courtesy of Analytical Chemistry)

Biosensor-Fabricated Wooden Tongue Depressor Measures Glucose and Nitrite in Saliva

Physicians often use tongue depressors to examine a patient's mouth and throat. However, it is hard to imagine that this simple wooden tool could actively assess a patient's health. This idea has led to... Read more


view channel
Image: The Atellica HEMA 570 and 580 hematology analyzers remove workflow barriers (Photo courtesy of Siemens)

Next-Gen Hematology Analyzers Eliminate Workflow Roadblocks and Achieve Fast Throughput

Hematology testing is a critical aspect of patient care, utilized to establish a patient's health baseline, track treatment progress, or guide timely modifications to care. However, increasing constraints... Read more


view channel
Image: The first ever diagnostic test accurately predicts patient response to immunotherapy (Photo courtesy of Cofactor)

Immunotherapy Predictive Test Could Spare Cancer Patients from Unnecessary Chemotherapy

In recent years, there has been a significant increase in clinical trials for new cancer drugs. However, only a select group of patients have found success with these newer immunotherapies, which utilize... Read more


view channel
Image: New method reveals bacterial reaction to antibiotics within minutes (Photo courtesy of Freepik)

New Method to Reveal Bacterial Reaction to Antibiotics in Five Minutes Could Help Create Rapid Molecular Test

Severely sick patients suffering from bacterial infections often require immediate treatment to prevent serious health complications, making it vital for physicians to quickly identify the appropriate antibiotic.... Read more


view channel
Image: navify digital solutions can helping labs mitigate unique quality challenges (Photo courtesy of Roche)

Cloud-Based Digital Solution Allows Labs to Track Test Samples along Entire Diagnostic Journey

Diagnosing a disease involves a meticulous procedure of monitoring a patient's diagnostic sample throughout its entire journey, which aids in clinical decision-making. However, there aren't any standardized... Read more


view channel
Electronic biosensor uses DNA aptamers for detecting biomarkers in whole blood samples (Photo courtesy of Freepik)

Electronic Biosensor Detects Biomarkers in Whole Blood Samples without Addition of Reagents

The absence of robust, reliable, and user-friendly bioanalytical tools for early and timely diagnosis of cardiovascular diseases, particularly sudden cardiac arrest, leads to preventable deaths and imposes... Read more


view channel
Image: The global hemostasis diagnostics market is expected to reach USD 3.95 billion by 2025 (Photo courtesy of Freepik)

Global Hemostasis Diagnostics Market Driven by Increase in Invasive Surgical Procedures

Injury or surgery naturally creates bleeding in living beings, which must be stopped to prevent excessive blood loss. The human body implements a protective mechanism known as hemostasis to stop excessive bleeding.... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.