We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Unique Blood Biomarker Shown to Effectively Monitor Sepsis Treatment

By LabMedica International staff writers
Posted on 12 Nov 2024

Sepsis remains a growing problem across the world, linked to high rates of mortality and morbidity. More...

Timely and accurate diagnosis, along with effective supportive therapy, is essential in reducing sepsis-related deaths. Now, a new study has found that a blood biomarker could serve as a promising clinical tool in antibiotic stewardship for sepsis management.

The study, conducted by scientists at the University of Uppsala (Uppsala, Sweden), aimed to assess the kinetics of four biomarkers in plasma from patients admitted to the ICU, including those with sepsis, and during antibiotic treatment. The study included 277 ICU patients, of whom 30% had sepsis, with the rest categorized as miscellaneous, other medical conditions, or trauma patients. Antibiotic treatment was either initiated or adjusted upon ICU admission. Plasma samples were collected at ICU admission and on days 2 and 3 of follow-up. The biomarkers studied were HBP (Heparin-binding protein), HNL Dimer (Human Neutrophil Lipocalin), HNL Total, and PCT (Procalcitonin). The data was compared to clinical scores like SOFA and KDIGO, as well as patient survival rates.

The study findings published in the journal PLOS ONE show that plasma levels of all four biomarkers were significantly elevated, with the highest concentrations observed in sepsis patients. Over the follow-up period, HNL Dimer levels decreased by day 2 and continued to drop by day 3 (p<0.00001), while the other three biomarkers remained unchanged. HNL Total demonstrated the strongest correlation with the clinical scores (p<0.0001) and was independently associated with these scores based on multiple regression analysis. These findings confirm their earlier research suggesting that HNL Dimer could be a valuable tool for antibiotic stewardship in sepsis, with HNL Total offering insight into epithelial cell activity and serving as a potential biomarker for managing organ failure in sepsis patients. 


Gold Member
Veterinary Hematology Analyzer
Exigo H400
Serological Pipet Controller
PIPETBOY GENIUS
New
Chlamydia Trachomatis Test
Aptima Chlamydia Trachomatis Assay
New
Staining System
RAL DIFF-QUIK
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Molecular Diagnostics

view channel
Image: Combining rapid diagnostic tests with conventional serology proves to be a useful strategy for diagnosing Chagas disease (Courtesy of Adobe Stock)

Rapid Tests for Chagas Disease Improves Diagnostic Access

Chagas disease, caused by the parasite Trypanosoma cruzi, affects between six and seven million people across the Americas. It is primarily transmitted by insect vectors and remains largely underdiagnosed,... Read more

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: How the predictive test works (Photo courtesy of QMUL)

World’s First Clinical Test Predicts Best Rheumatoid Arthritis Treatment

Rheumatoid arthritis (RA) is a chronic condition affecting 1 in 100 people in the UK today, causing the immune system to attack its joints. Unlike osteoarthritis, which is caused by wear and tear, RA can... Read more

Pathology

view channel
Image: A tool uses artificial intelligence and high-resolution imaging to track senescent cells (Courtesy of Adobe Stock)

AI-Assisted Technique Tracks Cells Damaged from Injury, Aging and Disease

Senescent cells, which stop growing and reproducing due to injury, aging, or disease, play a critical role in wound repair and aging-related diseases like cancer and heart disease. These cells, however,... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.