We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Unique Blood Biomarker Shown to Effectively Monitor Sepsis Treatment

By LabMedica International staff writers
Posted on 12 Nov 2024

Sepsis remains a growing problem across the world, linked to high rates of mortality and morbidity. More...

Timely and accurate diagnosis, along with effective supportive therapy, is essential in reducing sepsis-related deaths. Now, a new study has found that a blood biomarker could serve as a promising clinical tool in antibiotic stewardship for sepsis management.

The study, conducted by scientists at the University of Uppsala (Uppsala, Sweden), aimed to assess the kinetics of four biomarkers in plasma from patients admitted to the ICU, including those with sepsis, and during antibiotic treatment. The study included 277 ICU patients, of whom 30% had sepsis, with the rest categorized as miscellaneous, other medical conditions, or trauma patients. Antibiotic treatment was either initiated or adjusted upon ICU admission. Plasma samples were collected at ICU admission and on days 2 and 3 of follow-up. The biomarkers studied were HBP (Heparin-binding protein), HNL Dimer (Human Neutrophil Lipocalin), HNL Total, and PCT (Procalcitonin). The data was compared to clinical scores like SOFA and KDIGO, as well as patient survival rates.

The study findings published in the journal PLOS ONE show that plasma levels of all four biomarkers were significantly elevated, with the highest concentrations observed in sepsis patients. Over the follow-up period, HNL Dimer levels decreased by day 2 and continued to drop by day 3 (p<0.00001), while the other three biomarkers remained unchanged. HNL Total demonstrated the strongest correlation with the clinical scores (p<0.0001) and was independently associated with these scores based on multiple regression analysis. These findings confirm their earlier research suggesting that HNL Dimer could be a valuable tool for antibiotic stewardship in sepsis, with HNL Total offering insight into epithelial cell activity and serving as a potential biomarker for managing organ failure in sepsis patients. 


New
Gold Member
Hematology Analyzer
Medonic M32B
Collection and Transport System
PurSafe Plus®
New
Automated Chemiluminescence Immunoassay Analyzer
MS-i3080
New
Sperm Quality Analyis Kit
QwikCheck Beads Precision and Linearity Kit
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Molecular Diagnostics

view channel
Image: AiPlex VAS for the MosaiQ platform is designed to help reduce time-to-diagnosis for patients with autoimmune vasculitis (Photo courtesy of AliveDx)

Novel Multiplex Assay Supports Diagnosis of Autoimmune Vasculitis

Autoimmune vasculitis and related conditions are difficult to diagnose quickly and accurately, often requiring multiple tests to confirm the presence of specific autoantibodies. Traditional methods can... Read more

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Immunology

view channel
Image: The test could streamline clinical decision-making by identifying ideal candidates for immunotherapy upfront (Xiao, Y. et al. Cancer Biology & Medicine July 2025, 20250038)

Blood Test Predicts Immunotherapy Efficacy in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies, making immunotherapy a promising yet unpredictable option. Current biomarkers such as PD-L1 expression or tumor... Read more

Technology

view channel
Image: Conceptual design of the CORAL capsule for microbial sampling in the small intestine (H. Mohammed et al., Device (2025). DOI: 10.1016/j.device.2025.100904)

Coral-Inspired Capsule Samples Hidden Bacteria from Small Intestine

The gut microbiome has been linked to conditions ranging from immune disorders to mental health, yet conventional stool tests often fail to capture bacterial populations in the small intestine.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.