We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

Blood-Based Biomarker Test Predicts Progression to Alzheimer’s in At-Risk Population

By LabMedica International staff writers
Posted on 21 Sep 2023
Print article
Image: A blood biomarker can predict progression to Alzheimer’s disease in at-risk population (Photo courtesy of 123RF)
Image: A blood biomarker can predict progression to Alzheimer’s disease in at-risk population (Photo courtesy of 123RF)

In recent years, there's been an uptick in studies exploring the potential of blood biomarkers like plasma or serum neurofilament light (NfL) in gauging neurodegeneration in Alzheimer's disease (AD). Despite this interest, not many attempts have been made to combine existing findings to evaluate how effective NfL in the blood can be as a marker for neurodegeneration in AD. Moreover, we still need to understand which specific neurodegenerative changes correspond to increased levels of NfL in plasma or serum. Now, neuroscience researchers have confirmed that blood NfL levels can be a good indicator for predicting both the likelihood and rate of progression of neurodegenerative changes in Alzheimer’s disease.

NfL in the blood is easily measurable and minimally invasive, making it a practical choice for a clinical biomarker. While it's true that NfL levels rise during normal aging as a general sign of neuronal damage, the extent and rate of this increase are notably greater in cases of Alzheimer's. Neuroscience researchers at Wayne State University (Detroit, MI, USA) combed through existing studies to explore how NfL levels in blood relate to brain imaging data from MRI or PET scans. Their analysis indicates that elevated NfL levels in the blood correspond to more severe brain shrinkage, particularly in the medial temporal lobe. They also found that higher NfL concentrations are linked with lowered glucose metabolism in the brain and reduced integrity of white matter among those on the Alzheimer's spectrum.

Longitudinal studies have also consistently shown a meaningful connection between NfL levels in the blood and brain shrinkage in areas commonly affected by Alzheimer’s disease. Upon reviewing both cross-sectional and longitudinal data, it was clear that NfL levels in the blood can reliably predict the extent of both brain shrinkage and reduced glucose metabolism in regions frequently impacted by Alzheimer's pathology. The work by neuroscience researchers at Wayne State University highlights that not only is blood NfL effective in predicting how quickly neurodegeneration will progress, but it is also a valuable tool for evaluating the risk of cognitive decline in people who are otherwise mentally sound but have a higher risk for Alzheimer's. The research was published in the journal Brain, Aug. 4, 2023.

“The cross-sectional literature indicates that blood NfL shows great promise as a monitoring biomarker to indicate the severity of neurodegeneration in Alzheimer’s disease,” said Jessica Damoiseaux, Ph.D. “It could be especially useful in persons who show Alzheimer’s pathology but are at present cognitively unimpaired, or in people who are highly likely to develop Alzheimer’s disease due to having the APOE ε4 allele or higher Aβ load.”

Related Links:
Wayne State University

Platinum Supplier
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Gold Supplier
Automated Staining Unit
RAL Stainer
Complement 3 (C3) Test
GPP-100 C3 Kit
Enterovirus/Coxsackievirus A16/Enterovirus 71 RNA Diagnostic Kit
S3053E EV/EV71/CA16

Print article


Clinical Chemistry

view channel
Image: A module with eight micro-devices, complete with microfluidic channels and drive motors (Photo courtesy of U.S Department of Energy)

Highly Sensitive pH Sensor to Aid Detection of Cancers and Vector-Borne Viruses

Understanding the acidity or alkalinity of substances through pH measurement is crucial in many fields, from environmental monitoring to healthcare product safety. In many cases, these measurements must... Read more


view channel
Image: The QScout hematology analyzer has received US FDA 510(k) clearance (Photo courtesy of Ad Astra Diagnostics)

First Rapid-Result Hematology Analyzer Reports Measures of Infection and Severity at POC

Sepsis, a critical medical condition that arises as an extreme response to infection, poses a significant health threat. It occurs when an infection triggers a widespread inflammatory response in the body.... Read more


view channel
Image: PointCheck is the world’s first device for non-invasive white cell monitoring (Photo courtesy of Leuko Labs)

World’s First Portable, Non-Invasive WBC Monitoring Device to Eliminate Need for Blood Draw

One of the toughest challenges for cancer patients undergoing chemotherapy is experiencing a low count of white blood cells, also known as neutropenia. These cells play a crucial role in warding off infections.... Read more


view channel
Image: Current testing methods for antibiotic susceptibility rely on growing bacterial colonies in the presence of antibiotics (Photo courtesy of 123RF)

Rapid Antimicrobial Susceptibility Test Returns Results within 30 Minutes

In 2019, antimicrobial resistance (AMR) was responsible for the deaths of approximately 1.3 million individuals. The conventional approach for testing antimicrobial susceptibility involves cultivating... Read more


view channel
Image: AI methods used in satellite imaging can help researchers analyze tumor images (Photo courtesy of Karolinska Institutet)

AI Approach Combines Satellite Imaging and Ecology Techniques for Analysis of Tumor Tissue

Advancements in tumor imaging technology have significantly enhanced our ability to observe the minute details of tumors, but this also brings the challenge of interpreting vast amounts of data generated... Read more


view channel
Image: The acquisition significantly expands Medix Biochemica’s portfolio of IVD raw materials (Photo courtesy of ViroStat)

Medix Biochemica Acquires US-Based ViroStat to Expand Infectious Diseases Antibody Offering

Medix Biochemica (Espoo, Finland), a supplier of critical raw materials to the in vitro diagnostics (IVD) industry, has acquired ViroStat LLC (Portland, ME, USA), a provider of infectious disease antibodies... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.