We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App

Cheap, Non-Invasive Blood Test Predicts Alzheimer's Risk 20 Years Ahead of Symptoms

By LabMedica International staff writers
Posted on 20 Sep 2023
Print article
Image: A simple test can help predict risk of Alzheimer\'s disease 20 years in advance (Photo courtesy of 123RF)
Image: A simple test can help predict risk of Alzheimer\'s disease 20 years in advance (Photo courtesy of 123RF)

At present, Alzheimer's disease is usually identified through signs of cognitive decline, a stage where the brain has already sustained significant damage. Conventional methods for early detection are not only costly but also invasive, typically involving procedures like lumbar punctures that are both physically and emotionally strenuous for the patient. Now, a simple, cheap, and non-invasive blood test may be capable of assessing the likelihood of someone developing Alzheimer's up to two decades before any symptoms appear.

A team of physicists from The Australian National University (ANU, Canberra, Australia) has combined nanotechnology and artificial intelligence (AI) to analyze proteins in the blood for early indicators of neurodegeneration, or specific "biomarkers" signaling the onset of Alzheimer's. Proteins are essentially the foundation of life, containing unique genetic blueprints for each person that offer valuable insights into our health, including the degeneration of brain cells. Locating these proteins with early neurodegeneration markers is like finding a needle in a haystack, according to the researchers.

To tackle this, physicists at ANU have developed an ultra-thin silicon chip embedded with "nanopores," or tiny nanometer-sized holes, that single out proteins for analysis with the aid of a sophisticated AI algorithm. A tiny blood sample is placed on the silicon chip, which is then put into a handheld device roughly the size of a smartphone. This device employs the AI algorithm to sift through the blood sample for protein markers indicative of early-stage Alzheimer's. Notably, the researchers say that the algorithm has the potential to be adapted to screen for various neurological conditions concurrently, such as Parkinson's disease, multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). The ANU scientists anticipate that this screening method could become accessible within the next five years. The study has been published in the journal Small Methods.

"Blood is a complex fluid that contains more than 10,000 different biomolecules. By employing advanced filtration techniques and harnessing our nanopore platform, combined with our intelligent machine learning algorithms, we may be able to identify even the most elusive proteins," said ANU Ph.D. researcher Shankar Dutt.

Related Links:

Platinum Supplier
ADAMTS-13 Protease Activity Test
ATS-13 Activity Assay
Gold Supplier
Blood Glucose Reference Analyzer
Nova Primary
POCT Fluorescent Immunoassay Analyzer
ECP Test
Eosinophil Cationic Protein ELISA-Kit

Print article


Clinical Chemistry

view channel
Image: A module with eight micro-devices, complete with microfluidic channels and drive motors (Photo courtesy of U.S Department of Energy)

Highly Sensitive pH Sensor to Aid Detection of Cancers and Vector-Borne Viruses

Understanding the acidity or alkalinity of substances through pH measurement is crucial in many fields, from environmental monitoring to healthcare product safety. In many cases, these measurements must... Read more


view channel
Image: The QScout hematology analyzer has received US FDA 510(k) clearance (Photo courtesy of Ad Astra Diagnostics)

First Rapid-Result Hematology Analyzer Reports Measures of Infection and Severity at POC

Sepsis, a critical medical condition that arises as an extreme response to infection, poses a significant health threat. It occurs when an infection triggers a widespread inflammatory response in the body.... Read more


view channel
Image: PointCheck is the world’s first device for non-invasive white cell monitoring (Photo courtesy of Leuko Labs)

World’s First Portable, Non-Invasive WBC Monitoring Device to Eliminate Need for Blood Draw

One of the toughest challenges for cancer patients undergoing chemotherapy is experiencing a low count of white blood cells, also known as neutropenia. These cells play a crucial role in warding off infections.... Read more


view channel
Image: Current testing methods for antibiotic susceptibility rely on growing bacterial colonies in the presence of antibiotics (Photo courtesy of 123RF)

Rapid Antimicrobial Susceptibility Test Returns Results within 30 Minutes

In 2019, antimicrobial resistance (AMR) was responsible for the deaths of approximately 1.3 million individuals. The conventional approach for testing antimicrobial susceptibility involves cultivating... Read more


view channel
Image: AI methods used in satellite imaging can help researchers analyze tumor images (Photo courtesy of Karolinska Institutet)

AI Approach Combines Satellite Imaging and Ecology Techniques for Analysis of Tumor Tissue

Advancements in tumor imaging technology have significantly enhanced our ability to observe the minute details of tumors, but this also brings the challenge of interpreting vast amounts of data generated... Read more


view channel
Image: The acquisition significantly expands Medix Biochemica’s portfolio of IVD raw materials (Photo courtesy of ViroStat)

Medix Biochemica Acquires US-Based ViroStat to Expand Infectious Diseases Antibody Offering

Medix Biochemica (Espoo, Finland), a supplier of critical raw materials to the in vitro diagnostics (IVD) industry, has acquired ViroStat LLC (Portland, ME, USA), a provider of infectious disease antibodies... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.