We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Breakthrough Microfluidic Device Could Revolutionize Diagnosis and Treatment of Cancer

By LabMedica International staff writers
Posted on 10 May 2023
Print article
Image: Cyto-Mine single cell analysis system (Photo courtesy of Sphere Fluidics)
Image: Cyto-Mine single cell analysis system (Photo courtesy of Sphere Fluidics)

A new European initiative seeks to advance microfluidic technology for isolating and cultivating circulating tumor cells, which could potentially predict cancer metastasis and direct treatment strategies.

The project, dubbed 3DSecret, brings together a diverse group of experts in microfluidics, nanosensors, artificial intelligence (AI), cell genomics, and transcriptomics from Portugal, Spain, Italy, and the UK, and a consortium partner, Sphere Fluidics (Cambridge, UK). The primary objective of 3DSecret is to create technologies that can unveil the random patterns behind metastasis at a single-cell level and predict cancer progression. The team plans to develop a microfluidic platform to isolate circulating tumor cells and cultivate them into three-dimensional spheroids containing 100 to 1,000 cells for comprehensive analysis. This process will involve surface-enhanced Raman spectroscopy (SERS) metabolomics profiling to track spheroid growth kinetics and spheroid sequencing.

These spheroids will maintain the clonal information from the originating cell, eliminating the need for DNA amplification and thus reducing sequencing costs. The gathered metabolomics and genomics data will feed an AI algorithm that will ultimately be capable of pinpointing cells responsible for metastasis and identifying other underlying patterns. In the future, such tools could help diagnose cancer and direct disease treatment, such as estimating a patient's malignancy score from a liquid biopsy. This technology could also facilitate the identification of potential "metastatic-associated -omic panels" and serve as a platform for drug testing.

As a consortium partner, Sphere Fluidics is offering its microfluidic, droplet-based Cyto-Mine single-cell isolation and assay platform, which integrates cell isolation, screening, sorting, imaging, and verification. Sphere Fluidics will also support the development of a unified microfluidic device called the 3DSecret-chip, designed to form 3D spheroids from individual cancer cells.

“The 3DSecret project, besides having the potential to unlock hidden mechanisms behind metastasis, will provide bleeding tech breakthrough developments to the fields of microfluidics, single-cell studies, sequencing and AI applied to health,” said Dr. Sara Abalde-Cela, Project Coordinator, 3DSecret.

“The anticipated technical and scientific discoveries within the 3DSecret program hold great potential to revolutionize the diagnosis and treatment of cancer by taking a radical bottom-up holistic approach: from cancer single-cells to 3D spheroids,” added Dr. Frank F Craig, CEO, Sphere Fluidics. “Following funding, we’re now excited to get started on the project and initiate the collaboration amongst consortium members, which will be key to 3DSecret’s hopeful breakthrough. Through our involvement, we are further demonstrating the scope of applications our technology can support to facilitate cutting-edge biotherapeutic discovery and development.”

Related Links:
Sphere Fluidics 

Unit-Dose Twist-Tip BFS
Gold Supplier
Virus Detection System
Lung Cancer Molecular Diagnostic Test
Auto Clinical Chemistry Analyzer
ChemiLab 100

Print article


Clinical Chem.

view channel
Image: Electrochemical cells etched by laser on wooden tongue depressor measure glucose and nitrite in saliva (Photo courtesy of Analytical Chemistry)

Biosensor-Fabricated Wooden Tongue Depressor Measures Glucose and Nitrite in Saliva

Physicians often use tongue depressors to examine a patient's mouth and throat. However, it is hard to imagine that this simple wooden tool could actively assess a patient's health. This idea has led to... Read more


view channel
Image: The Atellica HEMA 570 and 580 hematology analyzers remove workflow barriers (Photo courtesy of Siemens)

Next-Gen Hematology Analyzers Eliminate Workflow Roadblocks and Achieve Fast Throughput

Hematology testing is a critical aspect of patient care, utilized to establish a patient's health baseline, track treatment progress, or guide timely modifications to care. However, increasing constraints... Read more


view channel
Image: The first ever diagnostic test accurately predicts patient response to immunotherapy (Photo courtesy of Cofactor)

Immunotherapy Predictive Test Could Spare Cancer Patients from Unnecessary Chemotherapy

In recent years, there has been a significant increase in clinical trials for new cancer drugs. However, only a select group of patients have found success with these newer immunotherapies, which utilize... Read more


view channel
Image: New method reveals bacterial reaction to antibiotics within minutes (Photo courtesy of Freepik)

New Method to Reveal Bacterial Reaction to Antibiotics in Five Minutes Could Help Create Rapid Molecular Test

Severely sick patients suffering from bacterial infections often require immediate treatment to prevent serious health complications, making it vital for physicians to quickly identify the appropriate antibiotic.... Read more


view channel
Image: navify digital solutions can helping labs mitigate unique quality challenges (Photo courtesy of Roche)

Cloud-Based Digital Solution Allows Labs to Track Test Samples along Entire Diagnostic Journey

Diagnosing a disease involves a meticulous procedure of monitoring a patient's diagnostic sample throughout its entire journey, which aids in clinical decision-making. However, there aren't any standardized... Read more


view channel
Electronic biosensor uses DNA aptamers for detecting biomarkers in whole blood samples (Photo courtesy of Freepik)

Electronic Biosensor Detects Biomarkers in Whole Blood Samples without Addition of Reagents

The absence of robust, reliable, and user-friendly bioanalytical tools for early and timely diagnosis of cardiovascular diseases, particularly sudden cardiac arrest, leads to preventable deaths and imposes... Read more


view channel
Image: The global hemostasis diagnostics market is expected to reach USD 3.95 billion by 2025 (Photo courtesy of Freepik)

Global Hemostasis Diagnostics Market Driven by Increase in Invasive Surgical Procedures

Injury or surgery naturally creates bleeding in living beings, which must be stopped to prevent excessive blood loss. The human body implements a protective mechanism known as hemostasis to stop excessive bleeding.... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.