We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBE SCIENTIFIC, LLC

EUROIMMUN AG

EUROIMMUN is an international provider of medical laboratory products for autoimmune, infection, allergy and molecula... read more Featured Products: More products

Download Mobile App




Serological Biomarker Aids Diagnosis of Rare Kidney Disease Without Biopsy

By LabMedica International staff writers
Posted on 15 Jun 2022

Primary membranous nephropathy (pMN) is a chronic inflammatory kidney disease that can lead to kidney failure. More...

Antibodies against PLA2R (phospholipase A2 receptors) occur with a prevalence of 70 to 80% and a specificity of over 99%. Anti-PLA2R have been recognized as a significant serological biomarker for the diagnosis of pMN in the new guideline from the KDIGO (Kidney Disease: Improving Global Outcomes). Diagnosis of pMN can now be made without biopsy if the serological marker anti-PLA2R is present alongside the clinical symptoms.

Antibodies in pMN can be determined using exclusive test systems from EUROIMMUN (Luebeck, Germany), a PerkinElmer, Inc. (Waltham, MA; USA) company. As well as aiding diagnosis, measurement of anti-PLA2R is also used to assess the activity and progression of pMN. Phases of clinical remission and relapses are typically preceded by a respective change in the antibody titer. The antibody concentration is one of the criteria used to assess the risk of progression to renal failure. Anti-PLA2R determination is suitable for assessing responses to immunosuppressive therapy. According to the guideline, the antibody concentration should be measured three or six months after the start of therapy. The determined value serves as a basis for maintaining or adjusting the current treatment.

The predictive value of anti-PLA2R antibodies is also relevant for assessing pMN patients undergoing kidney transplantation. High antibody titers before a transplant indicate a high risk of relapse. After transplantation, regular determination of the antibody level helps to predict possible relapses early, allowing prompt intervention. In addition to anti-PLA2R, autoantibodies against thrombospondin type 1 domain-containing 7A (THSD7A) also occur in pMN at a prevalence of 2 to 5% and a high specificity. As they primarily occur in anti-PLA2R-negative pMN patients, they play a complementary role in pMN serodiagnostics.

EUROIMMUN’s indirect immunofluorescence test (IIFT) enables qualitative to semi-quantitative detection of anti-PLA2R or anti-THSD7A antibodies using transfected cells expressing the corresponding antigen on their surface. Anti-PLA2R antibodies can be measured quantitatively using ELISA or chemiluminescence immunoassay (ChLIA) based on recombinant receptor. The quantitative measurement is highly suited to disease and therapy monitoring and can be performed efficiently at high throughput. The IIFT, ELISA and ChLIA procedures are all automatable.

Related Links:
EUROIMMUN 
PerkinElmer, Inc. 


Gold Member
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
Serological Pipet Controller
PIPETBOY GENIUS
New
Automated Biochemical Analyzer
iBC 900
New
Staining System
RAL DIFF-QUIK
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.