We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Newly Identified Genes May Help to Screen and Treat Individuals with Hearing Loss

By LabMedica International staff writers
Posted on 17 May 2022
Print article
Image: Researchers have identified 10 new genes linked with hearing loss (Photo courtesy of 123rf.com)
Image: Researchers have identified 10 new genes linked with hearing loss (Photo courtesy of 123rf.com)

A massive genome-wide association study (GWAS) identified 10 novel gene loci associated with hearing loss, which may aid in screening and treating the disorder.

Hearing loss is one of the top contributors to years lived with disability and is a risk factor for developing dementia. Hearing loss is a major medical problem worldwide with an estimated 2.4 billion individuals expected to have some form of hearing loss by the year 2050.

Molecular evidence on the cellular origins of hearing loss in humans is growing. In this regard, investigators at King's College London (United Kingdom) and colleagues at Karolinska Institute (Stockholm, Sweden) and Erasmus University (Rotterdam, Netherlands) performed a genome-wide association meta-analysis of clinically diagnosed and self-reported hearing impairment on 723,266 individuals. The study comprised 147,997 affected individuals and 575,269 control subjects including 60,941 affected individuals that were not included in a previously published GWAS meta-analysis.

Results of the meta-analysis revealed 48 genes linked to hearing loss, including 10 novel variants newly linked to hearing.

Contributing author Dr. Frances Williams, professor of genomic epidemiology at King's College London, said, "Our findings identify 10 genes newly linked with hearing loss. This study points to genes we could target for screening purposes, drug development. and even gene therapy in the future. This study provides a solid foundation for ultimately improving therapies against hearing loss."

The study was published in the May 16, 2022, online edition of the American Journal of Human Genetics.

Related Links:
King's College London 
Karolinska Institute 
Erasmus University 

 

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Plasma Control
Plasma Control Level 1

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The medical office procedure detects the key biomarker in Parkinson’s and related neurodegenerative diseases (Photo courtesy of BIDMC)

Simple Skin Biopsy Test Detects Parkinson’s and Related Neurodegenerative Diseases

Parkinson's disease and a group of related neurodegenerative disorders known as synucleinopathies impact millions globally. These conditions, including Parkinson’s disease (PD), dementia with Lewy bodies... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.