We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics - An LGC Company

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Lipid Profiling of Blood Samples Reveals Biomarkers for Cardiometabolic Disease Risk

By LabMedica International staff writers
Posted on 29 Apr 2022
Print article
Image: Lipidomics provides new biomarkers for cardiovascular disease and Type II diabetes (Photo courtesy of DIfE)
Image: Lipidomics provides new biomarkers for cardiovascular disease and Type II diabetes (Photo courtesy of DIfE)

A lipidomics-based analysis of plasma samples from a large cohort of participants identified several lipids associated with cardiometabolic disease risk that might serve as biomarkers for diagnosis of cardiovascular disease and Type II diabetes.

Lipidomics is the large-scale study of pathways and networks of cellular lipids in biological systems. The word "lipidome" is used to describe the complete lipid profile within a cell, tissue, organism, or ecosystem and is a subset of the "metabolome" which also includes the three other major classes of biological molecules: proteins/amino-acids, sugars, and nucleic acids. Lipidomics is a relatively recent research field that has been driven by rapid advances in technologies such as mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, fluorescence spectroscopy, dual polarization interferometry, and computational methods coupled with the recognition of the role of lipids in many metabolic diseases such as obesity, atherosclerosis, stroke, hypertension, and diabetes.

Cardiovascular disease is the leading cause of death worldwide, accounting for around 18 million deaths per year. People with Type II diabetes have a two- to threefold increased risk of suffering a heart attack or stroke. Accordingly, there is a great need to identify biomarkers that can indicate the development of disease at an early stage in order to prevent or at least mitigate its onset.

In this regard, investigators at the German Institute of Human Nutrition (DifE) of the German Center for Diabetes Research (Deutsches Zentrum fuer Diabetesforschung) evaluated the fatty acid profiles in 2,414 blood samples from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. The samples were collected as early as the 1990s and in part came from participants who developed cardiovascular disease or Type II diabetes in subsequent years.

Using high-throughput lipidomics, the investigators identified a total of 282 different lipids, 69 of which were associated with at least one of the two diseases. Several monoacylglycerols and 16 and 18 chain fatty acids in diacylglycerols were associated with both outcomes. Cholesteryl esters, free fatty acids, and sphingolipids were largely cardiovascular disease-specific, while several (glycero)phospholipids were Type II diabetes-specific.

First author Dr. Fabian Eichelmann, a researcher in the department of molecular epidemiology at the German Institute of Human Nutrition and at the German Center for Diabetes Research, said, "A statistical association with cardiovascular diseases was found for 49 lipids, which mainly belonged to the cholesterol esters and sphingolipids. Twelve lipids were associated with Type II diabetes, the majority of which were glycerol and phospholipids. An association with both diseases was seen for eight lipids, among which several monoacylglycerides stood out."

The study was published in the April 15, 2022, online edition of the journal Circulation.

Related Links:
German Institute of Human Nutrition 
German Center for Diabetes Research 


Gold Supplier
Automatic Biochemistry Analyzer
Biossays C8
Platinum Supplier
SARS-CoV-2 Reactive & Non-Reactive Controls
Qnostics SARS-CoV-2 Typing
Automated Nucleic Acid Extraction System
Urine Analyzer

Print article


Clinical Chem.

view channel
Image: The analysis pipeline used to investigate associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease (Photo courtesy of University College London)

Lipid Measurements Show Potential as Alzheimer’s Disease Biomarkers

Brain changes accompanying ageing are varied and can include pathologies that lead to cognitive impairment, the commonest of which is Alzheimer’s disease (AD). Identifying blood-based signatures of brain... Read more


view channel
Image: Standard test for multiple myeloma provides clues of a rare, more deadly type (Photo courtesy of Pexels)

Standard Blood Cancer Test Provides Clues of Rare IgD Multiple Myeloma

IgD myeloma accounts for about 1% of common blood cancer multiple myeloma and has a worse prognosis. Specific testing for IgD myeloma is available at a handful of reference labs across the US, but takes... Read more


view channel
Image: QIAGEN has acquired a majority stake in enzymes provider BLIRT S.A. (Photo courtesy of QIAGEN)

Qiagen Acquires Enzymes Provider Blirt to Strengthen Sample Technologies Business

QIAGEN N.V. (Venlo, Netherlands) has signed agreements to acquire a 96% majority ownership stake in BLIRT S.A. (Gdansk, Poland), a manufacturer of recombinant enzymes for the life science industry.... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.