Download Mobile App

Events

more events

13 Sep 2026 - 16 Sep 2026

EUROTOX 2026 – 60th Congress of the European Societies of Toxicology

14 Sep 2026 - 19 Sep 2026

48th Mexican National Congress of Clinical Chemistry and ExpoQuím

16 Sep 2026 - 19 Sep 2026

ESCV 2026 – 28th Annual Meeting of the European Society of Clinical Virology

Partner Sites

HospiMedica

Philips and Imricor Collaboration Advances MRI-Guided Cardiac Procedures

AI Tool Uses Mammograms to Detect Common Cardiovascular Diseases

Biodegradable Gastric Stent Could Eliminate Repeat Procedures After Bariatric Surgery

Abbott LAA Occluder Gains CE Mark for AFib Stroke Risk Reduction

Wearable Hormone Monitor Enables At-Home Detection of Primary Aldosteronism

Elevated Gene Expression Correlates with Prostate Cancer Severity

By LabMedica International staff writers
Posted on 10 Sep 2018

Elevated expression of the gene ANO7 has been shown to correlate with the severity and possible outcome of prostate cancer (PrCa).

Based on earlier studies showing that genetic signals at 2q37, the location of the prostate specific ANO7 gene were indicators of likelihood of developing prostate cancer, investigators at the University of Turku, Finland) focused on this gene as part of their effort to find germline biomarkers that could predict outcome of the disease.

To investigate, in detail, the associations between the ANO7 gene and PrCa risk and disease aggressiveness, ANO7 from castration resistant tumors was sequenced together with samples from unselected PrCa patients and unaffected males. More...

Two pathogenic variants were discovered and genotyped in 1769 patients and 1711 unaffected males.

Variant rs77559646 showed both risk and association with aggressive PrCa, while high ANO7 expression was independently linked to poor survival. ANO7 genotypes correlated with expression and biochemical relapse, suggesting that ANO7 was a potential PrCa susceptibility gene and that its elevated expression correlated with disease severity and outcome.

"We found that small genetic changes to the ANO7 gene increase a patient's risk of aggressive prostate cancer. One of the current biggest unmet needs in prostate cancer care is being able to diagnose aggressive cancers at an early stage. Genetic testing for ANO7 could help identify these patients sooner and may bring new opportunities for precision oncology in prostate cancer," said senior author Dr. Johanna Schleutker, professor of biomedicine of the University of Turku.

The study was published in the August 29, 2018, online edition of the International Journal of Cancer.

Related Links:
University of Turku

Visit expo >

Platinum Member

Automated Coagulation Analyzer

Hemolumi H6

Gold Member

Clinical Chemistry Assay

Sorbitol Dehydrogenase (SDH)

New

MR-proADM Test

B•R•A•H•M•S MR-proADM KRYPTOR test

Electrolyte Analyzer

BKE-B

Read the full article by registering today, it's FREE!

Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.

Free digital version edition of LabMedica International sent by email on regular basis
Free print version of LabMedica International magazine (available only outside USA and Canada).
Free and unlimited access to back issues of LabMedica International in digital format
Free LabMedica International Newsletter sent every week containing the latest news
Free breaking news sent via email
Free access to Events Calendar
Free access to LinkXpress new product services
REGISTRATION IS FREE AND EASY!

Sign in: Registered website members

Sign in: Registered magazine subscribers

Latest Molecular Diagnostics News

Channels

Clinical Chemistry

view channel

Hematology

view channel

New Genetic Findings Reveal Cause of Bone Marrow Failure Syndrome

Inherited bone marrow failure syndromes (IBMFS) impair the bone marrow’s ability to produce sufficient healthy blood cells and are associated with an increased risk of early-onset myelodysplastic syndromes (MDS).... Read more

Ultra-Portable Device Enables Finger-Prick Blood Testing at Home

Patients who need frequent blood tests often face repeated clinic visits that burden services and disrupt care. In the UK, millions of tests are performed each year to diagnose disease, guide therapy,... Read more

Age-Specific CBC Reference Intervals Support Pediatric Diagnosis in Vietnam

Complete blood count (CBC) results underpin pediatric evaluation for anemia, infection, inflammation, and platelet disorders. Yet laboratories in Vietnam have largely relied on reference intervals derived... Read more

Spectral Flow Cytometry Assay Enhances MRD Detection in Multiple Myeloma

Minimal residual disease (MRD) monitoring is pivotal in multiple myeloma, where persistent malignant plasma cells drive relapse risk and help guide therapy decisions. In the United States, approximately... Read more

Immunology

view channel

Gut “Memory” May Explain Why IBD Flares Return

Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are characterized by recurring flare-ups that damage the intestinal mucosa and remain difficult to predict.... Read more

Image: Pre-existing antibody patterns may reveal how strongly a person will respond to vaccination, helping identify individuals at risk of a blunted immune response (Image Credit: Jason Drees, Biodesign Institute At Arizona State University)

AI-Based Antibody Profiling Predicts Strength of COVID-19 Vaccine Response

Vaccine-induced protection can vary widely between individuals, creating uncertainty for clinicians, particularly in patients with immunosuppressive conditions. Demographic and health factors explain only... Read more

Immune Biomarkers May Predict Recurrent Checkpoint Inhibitor Arthritis

Inflammatory arthritis is a recognized immune-related adverse event in patients treated with immune checkpoint inhibitors (ICIs) for cancer. Between 20% and 50% of affected patients experience more than... Read more

Image: The findings highlight the potential of blood-based immune profiling to provide a more comprehensive picture of how patients respond to immunotherapy. (Image Credit: Adobe Stock)

Immune Cell Blood Test May Predict Melanoma Immunotherapy Response

Melanoma remains one of the deadliest skin cancers, although outcomes improve markedly when the disease is detected early. Immunotherapy has extended survival for many patients with advanced melanoma,... Read more

Microbiology

view channel

Image: The “broth” used to monitor red blood cell depletion in whole blood spiked with one colony-forming-unit of E. coli bacteria, each incubated at different orbital shaking speeds—left to right: 0 RPM, 65 RPM, 120 RPM and 200 RPM—after four hours of incubation. This culturing raises a bacteria-rich, plasma-like layer of bacteria to the top of the vials, while clusters of stuck blood cells known as a Rouleaux formation sink to the bottom. (Image Credit: Pak Kin Wong)

New Diagnostic Workflow Identifies Bloodstream Pathogens and Antibiotic Response in Hours

Sepsis is a life-threatening complication of infection that affects more than 1.5 million patients annually in the United States and contributes to roughly one in three in-hospital deaths.... Read more

Genetic Marker Identifies Emerging Resistance to Frontline Malaria Drugs

Artemisinin-based combination therapy remains central to controlling Plasmodium falciparum malaria, but emerging drug resistance is complicating treatment and surveillance. In Uganda and across sub-Saharan... Read more

Surveillance and Susceptibility Testing Track Rising Candida Auris in U.S.

Drug-resistant fungal infections are straining infection control and treatment in hospitals and long-term care facilities, where rapid transmission can lead to severe outcomes. Candida auris has expanded... Read more

Plasma Cell-Free DNA Test Enables Earlier Diagnosis of Invasive Fungal Infections

Invasive fungal infections disproportionately affect immunocompromised patients, while diagnostic delays can contribute to substantial morbidity and mortality. Existing methods often depend on invasive... Read more

Pathology

view channel

Image: Researchers evaluated AI models that quantify tumor-infiltrating lymphocytes (TIL) on routine breast tissue slides, where higher TIL levels reflect stronger antitumor response and improved breast cancer outcomes (Image Credit: Shutterstock)

AI Matches Pathologists in Predicting Breast Cancer Prognosis from Immune Cells

Breast cancer is the most common cancer in Australian women, with more than 20,000 cases each year. Prognosis can be informed by counting tumor-infiltrating lymphocytes (TILs) on routine pathology slides,... Read more

AI-Pathologist Framework Improves Accuracy and Reliability in Cancer Diagnosis

Ensuring reliable cancer diagnosis from digital pathology remains a critical challenge as clinical decisions rely on accurate slide interpretation. While artificial intelligence (AI) has accelerated whole-slide... Read more

New Review Highlights Intelligent Agents as Next Step for Digital Pathology

Digital pathology remains constrained by models that classify single images without mirroring how clinicians interrogate multiple slides, adjust magnification, and synthesize ancillary tests.... Read more

Image: Adrenal gland tumor stained with hematoxylin and eosin (top) and CYP11B2 (bottom) (Photo courtesy of Christofer Juhlin)

Simple Immunohistochemical Size Ratio Improves Classification of Primary Aldosteronism

Primary aldosteronism is a common but underdiagnosed cause of hypertension, in which excess aldosterone promotes salt retention and raises blood pressure. Identifying the dominant source of hormone overproduction... Read more

Technology

view channel

Autonomous Robotic System Receives FDA Authorization for Blood Collection

Venipuncture is central to many diagnostic pathways, but routine blood collection can be affected by staffing constraints and procedural variability that influence consistency and patient experience.... Read more

Interoperable Data Platform Standardizes Multi-Cancer Blood Test Results

Proteotype Diagnostics has introduced Alchemi, a proprietary data and clinical workflow platform being developed for Enlighten, the company’s investigational blood-based multi-cancer test.... Read more

Training Device Improves Accuracy of Pooled Molecular Diagnostics

High-throughput molecular diagnostics have transformed infectious disease detection, but many workflows remain difficult to execute accurately without extensive training. Sample pooling can cut per‑test... Read more

New CE-Certified Software Advances Whole-Genome Cancer Testing

European hospitals are increasingly using comprehensive tumor genomics to guide therapy, but routine whole genome sequencing (WGS) requires validated, regulation-compliant workflows. A newly CE-certified... Read more

Industry

view channel

$Image: RaDaR ST uses a tumor-informed approach that identifies up to 48 patient-specific variants through whole-exome sequencing and tracks those variants in plasma to detect circulating tumor DNA (ctDNA) at very low variant allele fractions (VAFs) (Photo courtesy of Neogenomics)$

Click for LinkXpress Reader Inquiry Service
Enter code to receive information:

Where I can find code?

LinkXpress

Download Mobile App

Trending Articles

Events

Partner Sites

HospiMedica

Elevated Gene Expression Correlates with Prostate Cancer Severity

Latest Molecular Diagnostics News

Channels

LabMedica

Channels

Features

Partner Sites

Archive: