Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Protein-Coding Genetic Variant Related to Crohn's Disease

By Labmedica staff writers
Posted on 21 May 2008
A protein-coding genetic variation was identified that provides evidence for an abnormal immune response to bacteria in the digestive tract that may lead to the intestinal inflammation characteristic of Crohn's disease.

A team of scientists tested DNA samples from patients with Crohn's disease, comparing them with normal DNA samples. More...
The investigators conducted a genome-wide association scan of approximately 20,000 ‘coding' genetic variants that are thought to produce functional changes at the protein level. A novel genetic variant in a gene was identified and verified that had not been previously associated with Crohn's disease. The protein-coding genetic variation identified provides evidence that an abnormal immune response to bacteria in the digestive tract may lead to the intestinal inflammation characteristic of Crohn's disease.

The University Hospital of the Christian-Albrechts University (Kiel, Germany), together with Applied Biosystems (Foster City, CA, USA), developed the methods that led to the identification of the novel genetic variant. The collaboration led to the discovery of another piece of the genetic puzzle that may predispose humans to Crohn's disease, demonstrating a discovery pipeline that can be applied to other common disorders. Applied Biosystems single nucleotide polymorphisms (SNPs) genotyping system and other Applied Biosystems technologies including the AB 3730 genetic analyzer and TaqMan SNP genotyping assays were used for the study.

The editors of Bio-IT [Information Technology] World honored Applied Biosystems and Christian-Albrechts University with a Bio-IT World 2008 Best Practices Award for Basic Research R&D.

Bio-IT World's Best Practices Award program, which was established in 2003, recognizes teams for their novel and innovative use of technology to improve the efficiency and economics of R&D, drug discovery, clinical research, and trials. The award program is meant to bring broader awareness to the life science field's most innovative best practices and encourage the sharing of information among the scientific community.

The results of this collaboration were published in the February 2007 issue of the journal Nature Genetics. In addition, Bio-IT World plans to publish more information about this study.


Related Links:
Christian-Albrechts University
Applied Biosystems

New
Gold Member
Aspiration System
VACUSAFE
POC Helicobacter Pylori Test Kit
Hepy Urease Test
New
HIV-1 Molecular Diagnostic Assay
AltoStar HIV RT-PCR Kit 1.5
New
Chromogenic Culture System
InTray™ COLOREX™ ECC
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Copyright © 2000-2026 Globetech Media. All rights reserved.