We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Eurofins Technologies

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
06 Jun 2020 - 09 Jun 2020
Virtual Venue
08 Jun 2020 - 11 Jun 2020
Virtual Venue

Smartphone-Based Optical Imaging Offers Onsite Diagnostics

By LabMedica International staff writers
Posted on 08 Feb 2017
Print article
Image: The smartphone-based optical imaging system uses different modes to display cell images (Photo courtesy of UCLA / Stockholm University / Uppsala University).
Image: The smartphone-based optical imaging system uses different modes to display cell images (Photo courtesy of UCLA / Stockholm University / Uppsala University).
A novel smartphone-based optical imaging and molecular assay system permits on-site diagnostics and facilitates transfer of molecular diagnostic data from the point-of-care (POC) to the point-of-expertise, providing a cost-effective means for molecular diagnostics even in resource-limited settings.

The device, which can image and analyze specific DNA sequences and genetic mutations in tumor cells and tissue samples without prior DNA extraction, was developed through the collaborative efforts of a group of investigators at the University of California, Los Angeles, Stockholm University, and Uppsala University.

The investigators used a three-dimensional printer to produce a lightweight optical attachment to be used with a standard smartphone camera. The device is able to capture multi-color fluorescence and bright-field images of the same quality as those obtained by traditional light microscopy.

The device analyzes a tissue or cell sample in a dedicated container by recording multi-mode images of the sample during processing and feeding the data to an algorithm. The algorithm automatically analyzes the images to read the sequenced bases of the extracted tumor DNA and identifies genetic mutations directly inside the tumor tissue.

“It is very important to have these molecular testing approaches at a doctor’s office or where care is being given,” said senior author Dr. Mats Nilsson, professor of biochemistry and biophysics at Stockholm and Uppsala Universities. “Oftentimes, advanced lab-based testing is performed at major hospitals, which is limiting, as not everyone has access to a hospital that can perform these tests.”

The device was described in detail in the January 17, 2017, online edition of the journal Nature Communications.

Print article



view channel
Image: Stenotrophomonas maltophilia colonies on sheep blood agar. Cultivation 48 hours in an aerobic atmosphere, 37 °C (Photo courtesy of microbiologyinpictures).

Global Spread of the Multi-Resistant Pathogen Stenotrophomonas Maltophilia Revealed

Stenotrophomonas maltophilia strains occur in several natural and human associated ecosystems. The bacterium was long regarded as relatively unproblematic, but is now considered to be one of the most feared... Read more
Copyright © 2000-2020 Globetech Media. All rights reserved.