We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

Cord Blood IgE Levels Tied To Allergy, Asthma Rates

By LabMedica International staff writers
Posted on 22 Aug 2022
Print article
Image: The BioIC Allergen Specific-IgE Detection Kit-AD 40 panel (Photo courtesy of Agnitio Science and Technology).
Image: The BioIC Allergen Specific-IgE Detection Kit-AD 40 panel (Photo courtesy of Agnitio Science and Technology).

The rising prevalence of allergic diseases worldwide represents an important health problem. Early identification of children at high risk of allergic diseases could be helpful for physicians to recommend preventive measures and apply early interventions.

Cord blood immunoglobulin E (IgE) has been considered as a potential marker for years due to its predictability for allergic diseases, but the results are controversial. Several studies have reported that elevated cord blood IgE may predict allergic diseases and/or allergic sensitization in childhood, whereas other studies failed to find it as a good predictor.

Immunologists at the Chang Gung Memorial Hospital (Taoyuan, Taiwan) included 566 children (321 boys; mean age, 6.5 ± 0.4 years) in a prospective population-based cohort study designed to longitudinally investigate the effects of early-life environmental exposures and genetic predisposition on childhood allergic outcomes. Blood samples were drawn for subsequent measurement of serum total and allergen-specific IgE. Measurements of nitric oxide (FeNO) and pulmonary function were performed in standard procedures.

Serum total IgE was determined by ImmunoCAP (Phadia, Uppsala, Sweden). Allergic sensitization was defined as a positive Phadia Phadiatop Infant test result (≧0.35 PAU/L), detecting allergen-specific IgE against a mix of common inhalant and food allergens. Serum levels of allergen-specific IgE were measured using an automated microfluidic-based multiplexed immunoassay system, the BioIC Allergen-specific IgE Detection Kit- AD40 Panel; Agnitio Science and Technology, Hsinchu, Taiwan). FeNO measurement was performed by chemiluminescence analyzer (CLD 88sp NO analyzer, Ecomedics, Duernten, Switzerland).

The investigators reported that cord blood IgE levels were significantly associated with FeNO levels and serum total IgE levels. Cord blood IgE levels were positively associated with allergic sensitization (adjusted odds ratio [AOR] = 2.22). Specifically, they found significant associations between elevated levels of IgE in cord blood and higher likelihoods for sensitization to house dust mites (Dermatophagoides pteronyssinus and D. farina), dog dander, egg yolk, garlic and baker’s yeast.

Subjects with cord blood IgE ≥0.24 kU/L (the optimal cutoff) were significantly associated with an increased risk of allergic sensitization (AOR = 2.63,) and asthma (AOR = 2.35) than those with cord blood IgE <0.24 kU/L. Subjects with cord blood IgE ≥0.24 kU/L had significantly higher FeNO levels than those with cord blood IgE <0.24 kU/L. There were no significant associations between cord blood IgE levels and pulmonary function parameters.

The authors concluded that that cord blood IgE ≥0.24 kU/L predicts allergic sensitization, FeNO elevation, and asthma among Asian schoolchildren. Specifically, cord blood IgE levels ≥0.24 kU/L was associated with a 2.6-fold increased risk of allergic sensitization, particularly sensitization to mites, animals, and foods, at six years of age. This study suggests that cord blood IgE levels would be useful for early identification of newborns at risk of subsequent allergic sensitization and allergic airway inflammation at school age. The study was published on August 1, 2022 in the journal Pediatric Allergy and Immunology.

Related Links:

Chang Gung Memorial Hospital
Agnitio Science and Technology

Platinum Supplier
ADAMTS-13 Protease Activity Test
ATS-13 Activity Assay
Gold Supplier
Rapid Flu Test
Influenza A&B Rapid Test Kit
Complement 3 (C3) Test
GPP-100 C3 Kit
C. difficile Rapid Test
Proflow C. difficile GDH Rapid Test Kit

Print article


Clinical Chemistry

view channel
Image: A module with eight micro-devices, complete with microfluidic channels and drive motors (Photo courtesy of U.S Department of Energy)

Highly Sensitive pH Sensor to Aid Detection of Cancers and Vector-Borne Viruses

Understanding the acidity or alkalinity of substances through pH measurement is crucial in many fields, from environmental monitoring to healthcare product safety. In many cases, these measurements must... Read more

Molecular Diagnostics

view channel
Image: Newly identified biomarkers may detect early cognitive decline via a blood test (Photo courtesy of 123RF)

Blood Tests to Enable Early Identification of Cognitive Decline and Personalized Treatments

Some individuals who have endured extreme stressors like psychiatric disorders or childhood abuse and neglect can experience a variety of health issues later in life, such as depression, anxiety, and cardiovascular... Read more


view channel
Image: The QScout hematology analyzer has received US FDA 510(k) clearance (Photo courtesy of Ad Astra Diagnostics)

First Rapid-Result Hematology Analyzer Reports Measures of Infection and Severity at POC

Sepsis, a critical medical condition that arises as an extreme response to infection, poses a significant health threat. It occurs when an infection triggers a widespread inflammatory response in the body.... Read more


view channel
Image: Current testing methods for antibiotic susceptibility rely on growing bacterial colonies in the presence of antibiotics (Photo courtesy of 123RF)

Rapid Antimicrobial Susceptibility Test Returns Results within 30 Minutes

In 2019, antimicrobial resistance (AMR) was responsible for the deaths of approximately 1.3 million individuals. The conventional approach for testing antimicrobial susceptibility involves cultivating... Read more


view channel
Image: AI methods used in satellite imaging can help researchers analyze tumor images (Photo courtesy of Karolinska Institutet)

AI Approach Combines Satellite Imaging and Ecology Techniques for Analysis of Tumor Tissue

Advancements in tumor imaging technology have significantly enhanced our ability to observe the minute details of tumors, but this also brings the challenge of interpreting vast amounts of data generated... Read more


view channel
Image: Made-to-order diagnostic tests may soon be on the horizon (Photo courtesy of McGill University)

Breakthrough in Diagnostic Technology Could Make On-The-Spot Testing Widely Accessible

Home testing gained significant importance during the COVID-19 pandemic, yet the availability of rapid tests is limited, and most of them can only drive one liquid across the strip, leading to continued... Read more


view channel
Image: The acquisition significantly expands Medix Biochemica’s portfolio of IVD raw materials (Photo courtesy of ViroStat)

Medix Biochemica Acquires US-Based ViroStat to Expand Infectious Diseases Antibody Offering

Medix Biochemica (Espoo, Finland), a supplier of critical raw materials to the in vitro diagnostics (IVD) industry, has acquired ViroStat LLC (Portland, ME, USA), a provider of infectious disease antibodies... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.