Researchers Produce Stable RNA Nanoparticles

However, investigators at the University of Cincinnati (OH, USA) have found a solution to this problem.

They reported in the December 14, 2010, online edition of the journal ACS Nano that chemically modified 2′-F (2′-fluoro) RNA was resistant to RNase digestion. The 2′-F RNA could be incorporated into nanoparticles that retained the RNA's property for correct folding in dimer formation, appropriate structure in pro-capsid binding, and its biological activity in packaging viral DNA and producing infectious viral particles.

The authors concluded that, "They had demonstrated that it is practical to produce RNase-resistant, biologically active, and stable RNA for application in nanotechnology.”

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