We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
Sekisui Diagnostics

Download Mobile App




Active Immunotherapy Blocks Formation of Tumor Blood Vessels

By LabMedica International staff writers
Posted on 28 Dec 2010
Cancer researchers using a novel method based on tumor cells taken from the patient, which have been engineered to secrete immune stimulating molecules and then returned to the patient, have found that this approach has a disruptive effect on the tumor's ability to create new blood vessels.

Investigators at the Dana-Farber Cancer Institute (Boston, MA, USA) vaccinated a group of clinically responsive cancer patients with lethally irradiated, autologous tumor cells engineered to secrete granulocyte‐macrophage colony stimulating factor (GM-CSF). More...
In addition, the patients received an antibody blockade of cytotoxic T lymphocyte–associated antigen-4 (CTLA-4).

Results published in the December 15, 2010, issue of the journal Cancer Research revealed that this type of immunotherapy stimulated a response in patients that caused the selective destruction of tumor blood vessels. Antibodies to angiopoietin-1 and angiopoietin-2 were generated that blocked Tie-2 binding, downstream signaling, endothelial cell tube formation, and macrophage chemotaxis.

"It appears that the body's own immune system can be used to develop a new way to block angiogenesis,” said senior author Dr. Glenn Dranoff, associate professor of medicine at the Dana-Farber Cancer Institute. "Angiogenesis involves multiple factors, and our studies suggest that it may be advantageous to target several of these at the same time, rather than only focus on one factor, such as vascular endothelial growth factor. Substantial evidence indicates that inhibiting angiogenesis is a validated strategy for cancer therapy, but current approaches are in need of further improvements.”

Related Links:

Dana-Farber Cancer Institute





Platinum Member
Automated Coagulation Analyzer
Hemolumi H6
Gold Member
NEW PRODUCT : SILICONE WASHING MACHINE TRAY COVER WITH VICOLAB SILICONE NET VICOLAB®
REGISTRED 682.9
HPV Test
Allplex HPV28 Detection
Manual Pipetting Aid
Pipette Controllers macro
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Clinical Chemistry

view channel
Image Credit: 123RF

Screening After Pneumococcal Disease May Reveal Undiagnosed Blood Cancer or Immune Disorders

Severe pneumococcal disease requiring hospitalization often presents as pneumonia, particularly in older adults and people with cancer or compromised immune function. Because M protein testing and antibody... Read more

Microbiology

view channel
Image Credit: 123RF

FDA-Cleared Multiplex PCR Test Detects 13 Respiratory Pathogens in a Single Sample

Respiratory tract infections can be difficult to distinguish at presentation because many cause overlapping, nonspecific symptoms and are initially grouped as influenza-like illnesses. Causes span a range... Read more

Technology

view channel
Image: The laser-based photoacoustic spectroscopy setup consists of a Mid-IR laser equipped with three QCL modules covering wavelengths from 5.6 μm to 12.9 μm, two silver coated mirrors (SCM), a dichroic mirror (DM) with a transmittance of 90%, a thermal power sensor head (PM) to monitor the output laser power, a mechanical chopper (MC) for frequency modulation and a CEPAS-detector with a self-designed swab holder (SH). (Credit: Graunke, T., Scholz, T., Pieniak, M. et al. Scientific Reports (2026). https://doi.org/10.1038/s41598-026-68298-9)

Laser-Based Swab Analysis Shows Promise for Detecting Disease-Linked Odor Patterns

Disease-related changes in volatile organic compounds can alter body odor, producing measurable patterns in exhaled breath and bodily fluids. Current analytical methods can be complex, time-consuming,... Read more

Industry

view channel
Image

Collaboration Combines AI Cognitive Assessment and RNA Blood Testing for Earlier Alzheimer’s Detection

Alzheimer’s disease is often identified only after substantial neurodegeneration, partly because current diagnostic pathways are fragmented and difficult to scale. As treatment shifts toward earlier intervention,... Read more
Copyright © 2000-2026 Globetech Media. All rights reserved.