New Cell Sorting System Developed for Advanced Life Science Research Applications

It was designed according to a scheme of modular architecture based on exchangeable detector options, hands-on controls, and sorting options that make it adaptable to a wide variety of site and application needs. The seven laser paths and seven-pinhole optical collection system in the Influx system supports 24 parameters simultaneously with a 24 x 24 compensation matrix.

The Influx system uses parallel electronics to reach a throughput rate of 200,000 events per second, independent of the number of lasers or parameters. Its fluidics design features a special acoustical coupling in the nozzle assembly to create droplets for sorting, while ensuring low shear stress to optimize cell viability, even at high pressures. Disposable fluidics allows the easy replacement of a sample line or the complete fluidics path from sheath tank to nozzle tip in order to maintain strict aseptic cell sorting.

A new dedicated software package uses industry-standard protocols to manage hundreds of system parameters, giving investigators a high level of control and engagement with the instrument to support advanced research applications. Software wizards and controls will assist investigators in classifying cell populations, performing compensation, monitoring sorting and analyzing results.

"Life science researchers on the vanguard of cellular analysis require flexible cell sorting systems to meet their ever-complex needs,” said James Glasscock, president, cell analysis at BD Biosciences. "The new BD Influx system rises to that challenge and is already in use in a leading institution performing advanced cell research.”

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