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Technology

Image: The NEBNext ultra directional RNA library prep kit (Photo courtesy of New England Biolabs).

Nanopore Sequencing Enables Outbreak Field Surveillance

Outbreaks of fever of unknown origin start with nonspecific symptoms and case definition is only slowly developed and adapted, therefore, identifying the causative agent is crucial to ensure suitable treatment and control measures. More...
03 Oct 2018
Image: A lunchbox-sized device for nucleic acid quantification that can be powered by sunlight, a flame or electricity enables the diagnosis of disease in settings with unreliable power supply (Photo courtesy of Cornell University).

Cancer Detection Device Proves Effective in Field Testing

A decentralized approach to diagnostics can decrease the time to treatment of infectious diseases in resource-limited settings, yet most modern diagnostic tools require stable electricity and are not portable. More...
01 Oct 2018
Image: The SpinDx system (Photo courtesy of Sandia National Laboratories).

Integrated LAMP and Immunoassay Platform Detect Diarrheal Disease

The challenges of diagnosing infectious disease, especially in the developing world, and the shortcomings of available instrumentation have exposed the need for portable, easy-to-use diagnostic tools capable of detecting the wide range of causative microbes while operating in low resource settings. More...
26 Sep 2018
Image: The matrix-assisted laser desorption ionization–time of flight mass spectrometer (Photo courtesy of Bruker Daltonics).

MALDI-TOF MS Used to Identify Pythiosis

Pythiosis is a life-threatening infectious disease caused by the oomycete Pythium insidiosum. The disease has been increasingly reported worldwide and most patients with pythiosis undergo surgical removal of an infected organ. More...
25 Sep 2018
Image: The Q Exactive hybrid quadrupole-orbitrap mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Residual Tissue Repositories Suitable for MS-Based Proteomics

Mass spectrometry-based proteomics has become a powerful tool for the identification and quantification of proteins from a wide variety of biological specimens. More...
12 Sep 2018
Image: Nucleic acid hybridization on an electrically reconfigurable network of gold-coated magnetic nanoparticles enables microRNA detection in blood (Photo courtesy of University of New South Wales).

Magnetic Nanoparticle Tool Developed to Detect MicroRNA

A magnetic nanoparticle-based technique has been developed to directly detect microRNA (miRNA) in unprocessed whole blood samples in about thirty minutes. Currently scientists use quantitative reverse-transcription polymerase chain reaction (qRT-PCR) to profile miRNA due to its usually high specificity and sensitivity. More...
12 Sep 2018
Image: A simple, paper-based test can quickly identify a falsified or substandard antibiotic (Photo courtesy of John Eisele).

Simple Paper Test Detects False or Substandard Antibiotics

In the developing world, the manufacture and the distribution of substandard, non-legitimate medicines is widespread. It has been estimated that up to 10% of all drugs worldwide could be falsified with up to 50% of those some form of antibiotics. More...
04 Sep 2018
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