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Molecular Diagnostics

Image: A CyTOF mass cytometer (Photo courtesy of Wikimedia Commons).

White Blood Cell Population May Serve as MS Biomarker

A discrete population of white blood cells was found to be present in samples taken from patients with multiple sclerosis (MS) and this group of cells may serve both diagnostic and therapeutic roles. More...
29 Jul 2019
Image: A photomicrograph of bone marrow aspirate showing the histologic correlate of multiple myeloma (Photo courtesy of Wikimedia Commons).

Annual Blood Tests Recommended for Patients with MGUS

Individuals with low-risk or intermediate-risk monoclonal gammopathy of undetermined significance (MGUS) can convert to high-risk MGUS and progress to multiple myeloma within five years, a finding that supports the need for annual blood testing and risk assessment for all individuals with MGUS or light-chain MGUS. More...
29 Jul 2019
Image: A Giemsa-stained, thin film blood smear that shows the presence of numerous of ring-form, Plasmodium falciparum trophozoites, with some infected red blood cells (RBCs) harboring multiple organisms (Photo courtesy of Steve Glenn/CDC).

Gene Deletions Affect Rapid Diagnostic Tests for Malaria

Prompt and accurate diagnosis of malaria is crucial for malaria case-management and control and elimination programs. While malaria diagnosis was historically based on symptoms alone, guidelines state that parasite-based diagnosis of malaria should be confirmed before treatment is given. More...
25 Jul 2019
Image: A diagram illustrating peripheral artery disease in the lower limbs (Photo courtesy of US National Institute of Health).

GWAS Links Novel Loci to Peripheral Artery Disease Risk

Peripheral artery disease (also called peripheral arterial disease, PAD)) is a common circulatory problem in which narrowed arteries reduce blood flow to the limbs. PAD most commonly affects arteries in the legs. Both PAD and coronary artery disease (CAD) are caused by atherosclerosis. More...
25 Jul 2019
Image: Bone marrow aspirate of a patient with myeloid leukemia associated with Down’s syndrome. The smear includes frequent atypical megakaryocytes. Blasts are increased (11%). As in the peripheral blood, a subset of the blasts has cytoplasmic blebs (Photo courtesy of Elizabeth L. Courville, MD).

Genetic Changes Linked to Leukemia in Down’s Syndrome Children

Of the 30% of children with Down's syndrome who are found to have 'myeloid preleukemia', only 10% of those will go on to develop myeloid leukemia (3% of all children with Down's syndrome). Until now, it was not understood why only some children with the GATA1 mutation were progressing to full leukemia, while others were not. More...
24 Jul 2019
Image: The MiSeq System: access focused applications such as targeted resequencing, metagenomics, small genome sequencing, targeted gene expression profiling (Photo courtesy of Illumina).

Next-Generation Sequencing Identifies Monogenic Diabetes

Monogenic diabetes is seen mainly in maturity onset diabetes of the young (MODY), and accounts for 1%–2% of all diabetes cases. In adults, monogenic diabetes is difficult to distinguish from common diabetes causes. More...
23 Jul 2019
Image: A micrograph showing an adenocarcinoma of the lung (Photo courtesy of Wikimedia Commons).

Metabolomics-Based Blood Test Used for Diagnosis of NSCLC

A metabolomics-based blood test may reduce the need to rely on low-dose CT (computed tomography) scans for the diagnosis of non-small-cell lung cancer (NSCLC). More...
22 Jul 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.

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