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BioResearch

Image: Pulmonary neuroendocrine cells (red) are rare cells found in clusters along the mammalian airway, where they act as sensors, sending information to the central nervous system. These clusters are found interspersed among other airway epithelial cells (green) (Photo courtesy of Dr. Leah Nantie, University of Wisconsin).

Pulmonary Neuroendocrine Cells Function as Airway Sensors to Control Immune Response in the Lung

Researchers have found that pulmonary neuroendocrine cells sense environmental stimuli and transmit this information to the nervous system, which orchestrates an immune response in the lung.  More...
24 Jan 2016
Image: Cross-section of a mouse aorta with a large plaque. Red lines near the top of the cross-section are the wall of the aorta. The plaque contains a dysfunctional buildup of immune macrophages (pink) and protein waste (green) (Photo courtesy of Dr. I. Sergin, Washington University School of Medicine).

Macrophages Lacking Ubiquitin-Binding Protein Stimulate Growth of Atherosclerotic Plaques

In a mouse model of atherosclerosis it was shown that while lack of the autophagy chaperone protein p62 prevented ubiquinated dysfunctional proteins from being sequestered in vesicles in the cytoplasm of macrophages, the presence of these proteins in the cell contributed to increased macrophage infiltration into atherosclerotic plaques and exacerbated atherosclerosis.  More...
24 Jan 2016

Biotech Companies Agree to Commercialize an Anticancer PARP Inhibitor Drug

A pair of Israeli and American biotech companies has agreed on the development and commercialization of an anticancer Poly(ADP-ribose) polymerase inhibitor drug.  More...
24 Jan 2016
Image: A microscopic image of glioblastoma cells growing along the fibers of the 3D scaffold (Image courtesy of (Photo courtesy of Dr. Andrew Wan laboratory, Institute of Bioengineering and Nanotechnology, Singapore).

Key Finding May Lead to Improved Treatment of Aggressive Brain Cancers

Researchers have shown an essential role for the cell microenvironment in the growth of glioblastoma brain cancer cells, a discovery that could lead to a breakthrough in fighting such deadly cancers.  More...
20 Jan 2016
Image: On the left are fluorescence-labeled cells with nanoparticles: The cellular nuclei are shown in blue, the fluorescence labeling is shown in green, and the nanoparticles in the cells are identified by arrows. The middle photo shows a blood vessel populated with these cells (green). On the right is a detailed image of a vascular wall with the eNOS protein identified (red) (Photo courtesy of Dr. Sarah Rieck/Dr. Sarah Vosen, University of Bonn).

Novel Combination of Nanotechnology and Gene Therapy Repairs Damaged Arterial Walls

Vascular disease researchers have demonstrated the possibility of using a combination of magnetic nanoparticles and virally-transported genes to repair damage and restore function in the walls of arteries following anti-arteriosclerosis treatment.  More...
20 Jan 2016
Image: Very high magnification micrograph of cutaneous T-cell lymphoma (Photo courtesy of Wikimedia Commons).

Bacterial Toxins Promote Growth of Rare Skin Cancer

Toxins secreted by some types of skin bacteria have been shown to promote the growth of the rare skin cancer, cutaneous T-cell lymphoma.  More...
19 Jan 2016
Image: X-ray structure of the ERK2 MAP kinase in its active form. Phosphorylated residues are displayed in red (Photo courtesy of Wikimedia Commons).

Blocking ERK Signaling Inhibits Growth of Some Pancreatic Cancer Cell Lines

A recent paper discussed the potential of a drug that suppressed the growth of a subset of KRAS-mutant pancreatic cancer cell lines by blocking the ERK component of the RAF-MEK-ERK molecular pathway.  More...
19 Jan 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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