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BioResearch

Image: The image shows tumor induced in a mouse following subcutaneous injection of cells containing the NUP160 - SLC3A3 fusion gene (Photo courtesy of Dr. Masatoshi Jinnin, Kumamoto University).

Fusion Gene Promotes Growth of Malignant Cutaneous Angiosarcoma

A team of Japanese cancer researchers highlighted the importance of an oncogenic fusion gene to the formation and progression of the malignant skin cancer cutaneous angiosarcoma.  More...
11 Nov 2015

New Study Explains How Some Cancers Survive Histone Deacetylase Inhibitor Treatment

Cancer researchers believe that they now understand why some types of tumor cells are resistant to an important class of drugs known as histone deacetylase inhibitors.  More...
10 Nov 2015
Image: MRI renderings of mouse brain tumors. Tumors treated with SKOG102 (lower panels) shrank by about half compared to tumors treated with a control (upper panels) (Photo courtesy of the University of California, San Diego).

Transcription Factor Inhibitors Block Growth of Lethal Brain Tumor

A new approach for treating the deadly brain tumor glioblastoma multiforme is based on small molecule inhibitors of the major class of protein signaling molecules known as transcription factors, which are essential for tumor survival and growth.  More...
10 Nov 2015
Image: Micrographs show a cardiac myocyte cell (top) and an attached fibroblast cell (bottom) in a rat heart, after the injection of the newly developed nanoparticle. In the second frame, red light has been applied. The red coloring indicates that the myocyte, which causes cardiac arrhythmia, has been killed, while the fibroblast remains unharmed (Photo courtesy of the University of Michigan).

Nanoparticle Targeting May Revolutionize Cardiac Photoablation Therapy

A light-based therapeutic approach to correct cardiac arrhythmia has been improved by the development of a nanotechnique that allows precise delivery of photosensitive molecules to malfunctioning cardiomyocytes while avoiding normal cells.   More...
09 Nov 2015
Image: A space-filling model of the PTEN protein (blue) complexed with tartaric acid (brown) (Photo courtesy of Wikimedia Commons).

Differential Gene Expression Aids Disseminated Tumor Cells Adapt to Diverse Microenvironments

A recent paper described how cancer cells that have broken away from a primary tumor are able to establish the conditions they need to survive in a distant site that possesses a quite different microenvironment.  More...
09 Nov 2015
Image: Structure of the ferritin complex. The toxic anticancer drug daunorubicin was sequestered at the core of the molecule, protected by the protein coat (Photo courtesy of Wikimedia Commons).

Apoferritin-Based Nanocapsules Used to Transport Toxic Anticancer Drug

A toxic anticancer therapeutic agent was encapsulated in capsules derived from apoferritin, which sequestered the drug until its selective delivery to cancer cells.  More...
08 Nov 2015
Image: Comparison of a knockout obese mouse (left) and a normal laboratory mouse (right). Lipid metabolism in mice was shown to be regulated by a group of microRNAs (Photo courtesy of Wikimedia Commons).

MicroRNAs Shown to Control Lipid and Cholesterol Metabolism in Mouse Models

A group of microRNAs was identified as modulators of lipid and cholesterol metabolism in two mouse models and may serve as targets for drugs designed to protect against cardiovascular diseases.  More...
08 Nov 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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