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Pathology

Image: A comparison of an unaffected brain and an affected brain with pachygyria (Photo courtesy of Case Western Reserve University School of Medicine).

Genetic Mutation Identified in Childhood Brain Disorder

Pachygyria is characterized by abnormal movement of brain nerve cells, known as neurons, during development of the brain and nervous system and is caused by a breakdown in the fetal neuronal migration process due to genetic or possibly environmental influences. More...
21 Aug 2018

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Image: Molecular basis of familial hypercholesterolemia with a dominant pattern of inheritance: impaired low-density lipoprotein cholesterol clearance due to variations in LDLR, APOB, PCSK9 (Photo courtesy of Mayo Clinic).

Genetic Testing for Hypercholesterolemia Improves Diagnosis

Familial Hypercholesterolemia (FH) is caused by a genetic defect that hinders the body's ability to remove low-density lipoprotein (LDL) cholesterol from the blood. High LDL levels in the blood are more likely to result in narrowing of the arteries, which puts patients at substantially higher lifetime risk for heart disease and stroke at an early age. More...
16 Aug 2018
Image: The Bladder EpiCheck diagnostic kit (Photo courtesy of Nucleix).

Urine Test Accurately Detects Bladder Cancer Recurrence

Urinary tests have been studied for the detection of bladder tumors; however, most of these tests have not been implemented in clinical practice because of cost issues, practical aspects, or insufficient sensitivity or specificity as compared to the gold standard. More...
10 Aug 2018
Image: A photomicrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma of the lung, from a fine needle aspiration specimen (Photo courtesy of Nephron).

Cancer Risk Assessed by Circulating Protein Biomarker Panel

The question has been asked whether a risk prediction model based on circulating protein biomarkers improve on a traditional risk prediction model for lung cancer and the current USA screening criteria. More...
10 Aug 2018
Image: The Applied Biosystems 7500 real-time PCR System (Photo courtesy of Thermo Fisher Scientific).

Infections Defined in Urothelial Bladder Tumors

Bladder cancer is estimated to be the 9th most common cancer worldwide and over 90% of bladder tumors are classed as urothelial bladder carcinomas (UBCs), with 75% to 80% presenting at non-muscle-invasive (NMIBC) stages and the remainder presenting at muscle-invasive (MIBC) and metastatic stages. More...
09 Aug 2018
Image: A diagram of the hypothesis for the onset mechanism of childhood steroid-sensitive nephrotic syndrome (Photo courtesy of Kobe University).

Susceptible Genes Identified for Childhood Kidney Disease

Childhood nephrotic syndrome, also known as nephrosis, is an incurable disease with an unknown cause, characterized by large amounts of protein leaving the body in the patient's urine, and protein levels in the bloodstream becoming extremely low. More...
09 Aug 2018
Image: A histopathology of adenoid cystic/basal cell carcinoma of the prostate gland (Photo courtesy of Nephron).

Genetic Alterations Correlated to Aggressive Prostate Cancer

Prostate cancer is the second most common cancer among men, and while the disease is often indolent and treatable, some cases are aggressive. Distinguishing between the two could guide treatment decisions. More...
03 Aug 2018

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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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