We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App

Novel Immune-Based Biomarker Helps Detect Ovarian Cancer Years before Diagnosis

By LabMedica International staff writers
Posted on 18 Jun 2024
Print article
Image: The new immune-based biomarker could pave the way for early detection HGOC (Photo courtesy of 123RF)
Image: The new immune-based biomarker could pave the way for early detection HGOC (Photo courtesy of 123RF)

High-grade ovarian cancer (HGOC) ranks as the fifth-leading cause of cancer-related death among women. Over 90% of cases are diagnosed at advanced stages after the cancer has spread, posing significant challenges for treatment. While ovarian cancer is highly treatable if detected early, existing tests for conventional biomarkers have been unable to identify the microscopic, metastatic early lesions often located in the fallopian tubes. However, the discovery of a new immune-based biomarker could now significantly change the outlook for many women.

Researchers at Children's Hospital of Philadelphia (CHOP, Philadelphia, PA, USA) have identified a novel immune-based biomarker that could facilitate the early detection of HGOC, potentially saving lives. In their research, they analyzed T-cell receptors (TCRs) in nearly 500 blood samples from individuals who were pre-diagnostically identified with ovarian cancer, as well as from healthy or benign controls. TCRs are proteins on T cells, which are a type of immune cell that recognizes and attaches to foreign particles. Their findings indicated that in the initial stages of HGOC, roughly two to four years before the disease is typically diagnosed, the immune system reacts more strongly, producing a measurable biomarker.

From this, the researchers concluded that monitoring this disease within that specific timeframe, before there are noticeable changes in the body’s immune response, could allow for earlier therapeutic interventions. They also noted that further research is necessary to develop a diagnostic test that is sensitive enough to detect the novel immune biomarker. The aim is for such testing to complement existing approved HGOC screening protocols.

"Early detection of ovarian cancer could mean the difference between life and death for millions of women," said Bo Li, PhD, a core faculty member in the Center for Computational and Genomic Medicine at Children's Hospital of Philadelphia. "We believe our findings can be a gamechanger, providing insights for the development of an immune-based biomarker to detect early-stage ovarian cancers, as well as helping to potentially advance pediatric cancer research." The findings were published in Cell Reports Medicine on June 14, 2024

Related Links:

Platinum Member
Flu SARS-CoV-2 Combo Test
OSOM® Flu SARS-CoV-2 Combo Test
Magnetic Bead Separation Modules
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
Liquid Ready-To-Use Lp(a) Reagent
Lipoprotein (a) Reagent

Print article


Clinical Chemistry

view channel
Image: The new DxC 500i Clinical Analyzer is an integrated clinical chemistry and immunoassay analyzer (Photo courtesy of Beckman Coulter Diagnostics)

Integrated Chemistry and Immunoassay Analyzer with Extensive Assay Menu Offers Flexibility, Scalability and Data Commutability

As global healthcare systems increasingly shift towards networked laboratory operational models to enhance efficiency and patient access, there is a greater need for innovative solutions tailored to the... Read more


view channel
Image: The Truvian diagnostic platform combines clinical chemistry, immunoassay and hematology testing in a single run (Photo courtesy of Truvian Health)

Automated Benchtop System to Bring Blood Testing To Anyone, Anywhere

Almost all medical decisions are dependent upon laboratory test results, which are essential for disease prevention and the management of chronic illnesses. However, routine blood testing remains limited worldwide.... Read more


view channel
Image: The Simplexa C. auris direct kit is a real-time polymerase chain reaction assay run on the LIAISON MDX instrument (Photo courtesy of Diasorin)

Novel Molecular Test to Help Prevent and Control Multi Drug-Resistant Fungal Pathogen in Healthcare Settings

Candida auris (C. auris) is a rapidly emerging multi drug-resistant fungal pathogen that is commonly found in healthcare environments, where it presents a challenge due to its ability to asymptomatically... Read more


view channel
Image: Color-enhanced scanning electron micrograph showing Salmonella Typhimurium (red) invading cultured human cells (Photo courtesy of Rocky Mountain Laboratories, NIAID, NIH)

AI Identifies Drug-Resistant Typhoid-Like Infection from Microscopy Images within Hours

Antimicrobial resistance is becoming a serious global health concern, making many infections increasingly difficult to treat and limiting available treatment options. This escalation in resistance raises... Read more


view channel
Image: Beckman Coulter will utilize the ALZpath pTau217 antibody to detect key biomarker for Alzheimer\'s disease on its DxI 9000 immunoassay analyzer (Photo courtesy of Beckman Coulter)

Beckman Coulter Licenses Alzpath's Proprietary P-tau 217 Antibody to Develop Alzheimer's Blood Test

Cognitive assessments have traditionally been the primary method for diagnosing Alzheimer’s disease, but this approach has its limitations as symptoms become apparent only after significant brain changes... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.