We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Chromosome Instability Patterns Predict Tumor Drug Response

By LabMedica International staff writers
Posted on 16 Jun 2022

By analyzing the differences in the number of repetitions of sequences of DNA within cancerous tumors, genomic researchers characterized 17 different types of chromosomal instability, which could be used to predict tumor drug response and to aid in the identifying future drug targets. More...

Chromosomal instability (CIN) is a type of genomic instability in which chromosomes are unstable, such that either whole chromosomes or parts of chromosomes are duplicated or deleted. Chromosomal instability is a common feature of cancer, occurring in around 80% of tumors, researchers are only now beginning to understand exactly what types or patterns of instability are present in any given tumor.

To increase this understanding, investigators at the University of Cambridge (United Kingdom) and colleagues at the Spanish National Cancer Research Center (Madrid, Spain) evaluated the extent, diversity, and origin of CIN across 7,880 tumors representing 33 cancer types.

Results of this evaluation revealed 17 different types of chromosomal instability. These chromosomal instability signatures could be used to predict how tumors might respond to drugs, as well as aiding in the identification of future drug targets.

Senior author Dr. Florian Markowetz, senior group leader at the Cancer Research UK Cambridge Institute of the University of Cambridge, said, "The more complex the genetic changes that underlie a cancer, the more difficult they are to interpret and the more challenging it is to treat the tumor. This is tragically clear from the very low survival rates for cancers that arise as a result of chromosomal instability. Our discovery offers hope that we can turn things around, providing much more sophisticated and accurate treatments. We are now working hard to bring our technology to patients and develop it to a level where it can transform patients' lives."

The CIN study was published in the June 15, 2022, online edition of the journal Nature.

Related Links:
University of Cambridge 
Spanish National Cancer Research Center 

 


New
Gold Member
Collection and Transport System
PurSafe Plus®
Portable Electronic Pipette
Mini 96
New
Hemodynamic System Monitor
OptoMonitor
New
Human Estradiol Assay
Human Estradiol CLIA Kit
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Immunology

view channel
Image: The VENTANA HER2 (4B5) test is now CE-IVDR approved (Photo courtesy of Roche)

Companion Diagnostic Test Identifies HER2-Ultralow Breast Cancer and Biliary Tract Cancer Patients

Breast cancer is the most common cancer in Europe, with more than 564,000 new cases and 145,000 deaths annually. Metastatic breast cancer is rising in younger populations and remains the leading cause... Read more

Pathology

view channel
Image: An adult fibrosarcoma case report has shown the importance of early diagnosis and targeted therapy (Photo courtesy of Sultana and Sailaja/Oncoscience)

Accurate Pathological Analysis Improves Treatment Outcomes for Adult Fibrosarcoma

Adult fibrosarcoma is a rare and highly aggressive malignancy that develops in connective tissue and often affects the limbs, trunk, or head and neck region. Diagnosis is complex because tumors can mimic... Read more

Technology

view channel
Image: Conceptual design of the CORAL capsule for microbial sampling in the small intestine (H. Mohammed et al., Device (2025). DOI: 10.1016/j.device.2025.100904)

Coral-Inspired Capsule Samples Hidden Bacteria from Small Intestine

The gut microbiome has been linked to conditions ranging from immune disorders to mental health, yet conventional stool tests often fail to capture bacterial populations in the small intestine.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.