We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




Degree of Amyloid-Beta Misfolding Is Predictor of Alzheimer’s Disease Risk

By Labmedica International staff writers
Posted on 28 Oct 2019
Print article
Image: A micrograph showing amyloid-beta (brown) in senile plaques of the cerebral cortex (upper left of image) and cerebral blood vessels (right of image) with immunostaining (Photo courtesy of Wikimedia Commons).
Image: A micrograph showing amyloid-beta (brown) in senile plaques of the cerebral cortex (upper left of image) and cerebral blood vessels (right of image) with immunostaining (Photo courtesy of Wikimedia Commons).
Measurement of misfolded Abeta (amyloid-beta) protein in blood plasma was shown to be a strong, specific risk prediction marker for clinical Alzheimer’s disease even many years before clinical diagnosis.

Since Alzheimer's disease (AD) has a long silent phase between the onset of the molecular defects that cause the disease and the appearance of diagnostically specific symptoms, identifying high-risk individuals is critical. In this regard, investigators at the German Cancer Research Center (Heidelberg, Germany) appraised the ability of Abeta misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD.

For this study, the investigators evaluated the initial blood samples of 150 ESTHER participants in whom dementia was subsequently diagnosed during the 14-year follow-up period. ESTHER was an epidemiologic study assessing chances of prevention and early detection of various chronic diseases including cancer among older adults.The samples were compared with those of 620 randomly selected control participants not known to have been diagnosed with dementia who correlated with the dementia participants in terms of age, sex, and level of education. In particular, associations between Abeta misfolding, APOE4, and other predictors with clinical AD, vascular dementia, and mixed dementia diagnoses were assessed.

Changes in Abeta concentration were determined using an immuno-infrared sensor, which measured the ratio of misfolded to normally folded Abeta. Misfolded proteins tended to aggregate in amyloid plaques, while healthy structures did not. The two structures absorbed infrared light at different frequencies, which enabled determination of the ratio of healthy to pathological Abeta in blood plasma samples.

Results revealed that Abeta misfolding was associated with 23-fold increased odds of clinical AD diagnosis within 14 years. With the exception of the APOE4 status, which showed a 2.4 times higher risk in those people who later went on to develop Alzheimer's disease, none of the factors related to pre-existing diseases (diabetes, high blood pressure, depression) or lifestyle factors (bodyweight, level of education) correlated with the risk of disease.

"Everyone is now pinning their hopes on using new treatment approaches during this symptom-free early stage of disease to take preventive steps. In order to conduct studies to test these approaches, we need to identify people who have a particularly high risk of developing Alzheimer's disease," said senior author Dr. Hermann Brenner, professor of clinical epidemiology and aging research at the German Cancer Research Center.

The Abeta study was published in the October 11, 2019, online edition of the journal Alzheimer's & Dementia.

Related Links:
German Cancer Research Center


Print article

Channels

Hematology

view channel
Image: A blood film showing neutrophils and lymphocytes and other white and red blood cells, and a platelet (Photo courtesy of University of Minnesota).

Hematological Ratios Associated with Mortality in Pediatric Trauma Patients

Trauma-related injury as a potential cause of death affects millions of people worldwide, especially in less developed countries and furthermore, it is the leading cause of mortality in pediatric trauma patients.... Read more
Copyright © 2000-2019 Globetech Media. All rights reserved.