We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
04 May 2021 - 07 May 2021
Virtual Venue

Immune Response to Insulin Identifies Risk of Juvenile-Diabetes

By LabMedica International staff writers
Posted on 08 Mar 2021
Print article
Image: Schematic diagram of Type 1 Diabetes (TID). Immune Response to Insulin Could Identify and Help Treat Those at Risk for TID (Photo courtesy of Harvard Medical school).
Image: Schematic diagram of Type 1 Diabetes (TID). Immune Response to Insulin Could Identify and Help Treat Those at Risk for TID (Photo courtesy of Harvard Medical school).
Type 1 diabetes (T1D), also known as juvenile diabetes, is a form of diabetes in which very little or no insulin is produced by the islets of Langerhans (containing β-cells) in the pancreas. Insulin is a hormone required for the body to use blood sugar.

T-cell responses to posttranslationally modified self-antigens are associated with many autoimmune disorders. Type 1 diabetes (T1D) is a prototypical organ-specific autoimmune disease that results from the T-cell–mediated destruction of insulin-producing β-cells within pancreatic islets. The natural history of the disease is such that it allows for the study of T-cell reactivity prior to the onset of clinical symptoms.

Diabetes Specialists at the University of Colorado Anschutz Medical Campus (Aurora, CO, USA) collected blood samples from genetically at-risk adolescents every six months for two years. The team measured T-cell responses from genetically at-risk individuals to both naturally occurring insulin and hybrid insulin peptides, novel neo-epitopes implicated in T1D pathogenesis.

The scientists reported that both proinflammatory (interferon-γ) and anti-inflammatory (interluekin-10) cytokine responses to hybrid insulin peptides (HIPs) were more robust than those to native peptides, and the ratio of such responses oscillated between pro- and anti-inflammatory over time. However, individuals who developed islet autoantibodies or progressed to clinical type 1 diabetes had predominantly inflammatory T-cell responses to HIPs. Additionally, several HIP T-cell responses correlated to worsening measurements of blood glucose, highlighting the relevance of T-cell responses to posttranslationally modified peptides prior to autoimmune disease development.

Aaron W. Michels, MD, an Associate Professor specializing in Endocrinology, Diabetes and Metabolism, and a senior study author, said, “We want to know why people develop T1D, and this research has helped provide a lot more information and data as to what it looks like when genetically at-risk individuals are headed towards clinical diagnosis. Ideally, you want to treat a disease when it’s active, so this is a need in our field to understand when people have an immune response directed against insulin producing cells.”

The authors concluded that their results have important implications to stratify the risk of developing T1D and identifying individuals who may benefit from immune intervention studies. The study was published on February 9, 2021 in the journal Proceedings of the National Academy of Sciences of the United States of America.

Related Links:
University of Colorado Anschutz Medical Campus

Gold Supplier
Virus Transport and Preservation Medium – Inactivated
Virus Transport and Preservation Medium – Inactivated
Gold Supplier
POC Analyzer
Epithod 616
Kantaro COVID-SeroKlir
Gold Supplier
COVID-19 Test

Print article
BIOHIT  Healthcare OY


Molecular Diagnostics

view channel
Image: The EZ DNA Methylation-Direct Kit (Photo courtesy of Zymo Research)

Leukocyte Epigenomics and Artificial Intelligence Predict Late-Onset Alzheimer’s Disease

Alzheimer’s Disease (AD) is the most common form of age-related dementia, accounting for 60%–80% of such cases. The disorder causes a wide range of significant mental and physical disabilities, with profound... Read more


view channel
Image: The Novodiag platform combines real-time PCR and microarray capabilities to provide high-level multiplexing (Photo courtesy of Mobidiag Ltd.)

Hologic to Acquire Mobidiag to Strengthen Diagnostic Testing Business

Hologic, Inc. (Marlborough, MA, USA) has signed a definitive agreement to acquire Mobidiag Ltd. (Espoo, Finland) in a USD 795 million transaction that will accelerate the global growth of Mobidiag’s differentiated... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.