We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Cardiac Biomarkers Investigated in Acquired Refractory Thrombocytopenic Purpura Patients

By LabMedica International staff writers
Posted on 21 Jun 2022
Print article
Image: Peripheral blood smear from a patient with thrombotic thrombocytopenic purpura showing microangiopathic hemolytic anemia with numerous schistocytes and thrombocytopenia (Photo courtesy of Cleveland Clinic)
Image: Peripheral blood smear from a patient with thrombotic thrombocytopenic purpura showing microangiopathic hemolytic anemia with numerous schistocytes and thrombocytopenia (Photo courtesy of Cleveland Clinic)

Thrombotic thrombocytopenic purpura (TTP) is a rare disorder that causes blood clots (thrombi) to form in small blood vessels throughout the body. These clots can cause serious medical problems if they block vessels and restrict blood flow to organs such as the brain, kidneys, and heart.

Cardiovascular complications of TTP were first reported in a patient whose postmortem autopsy revealed diffusive thrombosis of terminal arteries and capillaries. Subsequently studies demonstrated that acute myocardial infarction and cardiac arrest are the leading causes of death in patients with TTP.

Hematologists at The First Affiliated Hospital of Soochow University (Suzhou, China) enrolled patients in a study who were diagnosed with refractory TTP from 2013 through 2020. The inclusion criteria were: (1) fever, hematuria, neurological involvement, or other TTP manifestations; (2) acute peripheral thrombocytopenia (<100 × 109/L), but no other identifiable cause; (3) decreased ADAMTS13 activity level (<10%); (4) positive anti-ADAMTS13 autoantibodies; (5) failure of platelet response after 4–7 days of therapeutic plasma exchange (TPE); (6) a clinical deterioration in a patient receiving standard therapy.

Baseline characteristics, including demographic information, clinical manifestations, and previous medical history, were collected from electronic health records (EHR). Laboratory information, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal probrain natriuretic peptide (NT-proBNP), were collected and recorded on admission and on the next day after last TPE treatment, respectively.

The investigators reported of the 78 patients with refractory TTP that were included in the study, 21 patients died during hospitalization with a mortality rate of 26.9% (21/78) and a median time to in-hospital death of 8.05 days. On-admission serum hs-cTnT (66.15 [14–410] versus 29.31 [12.5–90.04] pg/mL), NT-proBNP (1401 [439.5–4,490] versus 1,200.6 [235.18–2,756] pg/mL), and the ASTL: ALT ratios (AAR: 1.97 [1.41–2.86] versus 1.56 [1.07–2.21]) were significantly increased in the patients who died in hospital compared to those who survived. Multivariate analysis showed that AAR after TPE was associated with overall mortality (OR: 4.45). The areas under the receiver operator characteristic curve (AUC) of AAR, hs-cTnT, and NT-proBNP for the association with mortality were 0.814, 0.840, and 0.829, respectively.

The authors concluded that their results suggest that increased post-TPE cardiac markers were associated with death in TTP. AAR is a strong predictor for mortality and may be used for risk stratification in future TTP management. The study was published on June 11, 2022 in the Journal of Clinical Laboratory Analysis.

Related Links:
The First Affiliated Hospital of Soochow University 

Gold Supplier
Influenza Type A & B Test
Influenza A+B DUO
New
Influenza A+B Test
Anyplex FluA/B Typing Real-Time Detection
New
1,5-AG Test
1,5-Anhydroglucitol Test Kit
New
Portable Molecular Workstation
iPonatic III

Print article
IIR Middle East

Channels

Technology

view channel
Image: OneDraw Blood Collection Device significantly reduces obstacles for drawing blood (Photo courtesy of Drawbridge Health)

Near Pain-Free Blood Collection Technology Enables High-Quality Testing

Blood tests help doctors diagnose diseases and conditions such as cancer, diabetes, anemia, and coronary heart disease, as well as evaluate organ functionality. They can also be used to identify disease... Read more

Industry

view channel
Image: The global infectious disease IVD market is expected to hit USD 57 billion by 2030 (Photo courtesy of Pexels)

Global Infectious Disease IVD Market Dominated by Molecular Diagnostics Technology

The global infectious disease in vitro diagnostics (IVD) market stood at USD 113.7 billion in 2021 and is expected to grow at a CAGR of -7.41% from 2022 to 2030 to hit around USD 56.89 billion by 2030,... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.