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Immunology

Image: Photomicrograph of classic Hodgkin lymphoma (cHL) fine needle aspiration from a lymph node. The micrograph shows a mixture of cells common in cHL: eosinophils, Reed-Sternberg cells, plasma cells, and histocytes (Photo courtesy of Nephron)

Flow Cytometric Immunophenotyping Assessed for Classic Hodgkin Lymphoma

The diagnosis of classic Hodgkin lymphoma (CHL) requires morphologic and immunophenotypic identification of neoplastic Hodgkin and Reed-Sternberg cells (collectively referred to as HRS cells) intermixed with a background of reactive lymphocytes, histiocytes, plasma cells, and eosinophils. More...
24 Mar 2022
Image: The Orbitrap Fusion Mass Spectrometer was used to identify the biomarker panel for risk of early respiratory failure following hematopoietic cell transplantation (Photo courtesy of Thermo Fisher Scientific)

Biomarker Panel for Risk of Early Respiratory Failure Following Hematopoietic Cell Transplantation

Allogeneic hematopoietic cell transplantation (HCT) is a life-saving therapy used for malignant and nonmalignant diseases. However, post-HCT pulmonary complications continue to be a significant problem. When severe, pulmonary complications can result in respiratory failure (RF), affecting 10% to 23% of patients. More...
23 Mar 2022
Image: The NanoSight NS300 utilizes the latest version of NanoSight’s particle characterization technology, Nanoparticle Tracking Analysis (NTA) (Photo courtesy of University of New South Wales)

Serum Extracellular Vesicle Arginase 1 Measured In T2DM

Serum extracellular vesicle (EV)-derived arginase 1 (ARG 1) plays a critical role in diabetes-associated endothelial dysfunction. This study was performed to determine the levels of serum EV-derived ARG 1 in T2DM and non-T2DM participants and to examine the association of serum EV-derived ARG 1 with T2DM incidence. More...
18 Mar 2022
Image: This digitally-colorized, scanning electron microscopic (SEM) photograph depicts a number of corkscrew-shaped, Leptospira sp. bacteria atop a 0.1µm polycarbonate filter (Photo courtesy of Janice Haney Carr/CDC)

Enzyme Immunoassays Developed for Serodiagnosis of Human Leptospirosis

The laborious microscopic agglutination test (MAT) is the gold standard serologic test for laboratory diagnosis of leptospirosis. We developed EIA based serologic assays using recombinant proteins (rLigA, rLigB, rLipL32) and whole-cell extracts from eight Leptospira serovars as antigen and assessed the diagnostic performance of the new assay. More...
14 Mar 2022
Image: Opisthorchiasis-associated cholangiocarcinoma. (A) Cholangiocarcinoma specimen showing adult worms in the bile duct (blue arrows). (B) Adult Opisthorchis viverrini recovered from the liver (Photo courtesy of Khon Kaen University)

Diagnostic Biomarker Predicts Risk of Opisthorchiasis Cholangiocarcinoma

Opisthorchiasis is caused by an infection with fish-borne liver flukes of the genus Opisthorchis. Opisthorchiasis frequently leads to chronic inflammation in the biliary tract and is classified as a group 1 biological carcinogen by the International Agency for Research on Cancer: a definitive risk for cholangiocarcinoma (CCA). More...
10 Mar 2022
Image: B•R•A•H•M•S KRYPTOR compact PLUS bench top analyzer is designed for small size routine laboratories with a need of up to eight different immunoassays and a throughput of up to approximately 60 test per hour. (Photo courtesy of Multi Sarana Medika)

Different Assay Evaluated for Thyroglobulin and Thyroglobulin Antibodies

International guidelines recommend fixed cut-off values for thyroglobulin (Tg). These cut-offs do not take potential assay differences into account. This study aimed to evaluate if different assays for Tg and Tg antibodies (TgAb) affect management guidance for differentiated thyroid cancer (DTC) patients. More...
07 Mar 2022
Image: Photomicrograph of cytomegalovirus colitis (Photo courtesy of Nephron)

Immunohistochemistry Evaluated for Tissue-Invasive Cytomegalovirus in Gastrointestinal Mucosal Biopsies

Cytomegalovirus (CMV) immunohistochemistry (IHC) is the most widely used method to diagnose CMV infection/reactivation in tissues in a pathology laboratory. More...
04 Mar 2022
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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