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Clinical Chemistry

Histopathology of acute pancreatitis: necrosis of pancreatic parenchyma (lower left) with acute inflammation and fat necrosis (right and upper part of photograph) (Photo courtesy of Florida State University College of Medicine)

Heparin-Binding Protein Levels Dramatically Increase in Acute Pancreatitis

Heparin-binding protein (HBP), also known as CAP37 and azurocidin, is a glycoprotein stored in azurophilic granules and secretory vesicles in neutrophils that is released upon neutrophil activation early in the systemic inflammatory response. More...
25 Sep 2021
The ARCHITECT i2000SR immunoassay analyzer (Photo courtesy of Abbott)

Maternal Lipid Profile Tied to Pediatric CHD Risk

Congenital heart disease (CHD among live births, is the major form of birth defect and the leading cause of childhood mortality with an incidence of 9.1‰. The occurrence of CHD is caused by many factors. More...
25 Sep 2021
VIASURE HLA Celiac Real Time PCR Detection Kit

CerTest VIASURE HLA Celiac RT PCR Kit Enables Rapid Resolution of HLA Haplotypes Associated with Celiac Disease

CerTest Biotec (Zaragoza, Spain) has developed a simple and ready to use real-time PCR for the detection of the principal alleles of the HLA system and the subsequent determination of the DQ2 and DQ8 antigens associated with Celiac disease (CD). More...
21 Sep 2021
Image: Viasure Real-time PCR kit (Photo courtesy of CerTest Biotec)

New Multiplex Assay for Rapid Diagnosis of Atypical Pneumonia

CerTest Biotec (Zaragoza, Spain) has developed and validated the CE-IVD multiplex assay VIASURE C. pneumoniae, M. pneumoniae & L. pneumophila real time PCR kit for the detection of principal pathogens implicated in atypical pneumoniae. More...
21 Sep 2021
Image: The BD FACSLyric Flow Cytometry System (Photo courtesy of BD Diagnostics)

Encephalitis After Immunotherapy Detected Early by Blood Test

Immunotherapy is very effective for many cancers, but the treatment can also cause autoimmune side effects. Encephalitis is one of the most serious and difficult-to-diagnose side effects of immunotherapy. More...
16 Sep 2021
Image: The EASY-nLC 1000 HPLC system is s a fully integrated, split-free, nanoflow liquid chromatograph optimized for separating biomolecules such as proteins and peptides (Photo courtesy of Thermo Fisher Scientific)

Blood-Based Biomarker Predicts Onset of Symptomatic Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, starting with a preclinical phase of normal cognition lasting approximately two decades. The formal diagnosis of AD dementia, relies on neuropsychological tests further confirmed by brain imaging and cerebrospinal fluid (CSF) sampling. More...
16 Sep 2021
Image: The AB SCIEX QTRAP 5500 System is a high sensitivity, bench top hybrid triple quadrupole-Linear Accelerator trap mass spectrometer designed for LC/MS/MS analyses (Photo courtesy of SCIEX)

Globotriaosylsphingosine Levels Measured in Fabry Disease Patients

Fabry disease (FD) is caused by an inborn error of glycosphingolipid metabolism, a genetic defect resulting in partial or complete deficiency of the lysosomal hydrolase alpha-galactosidase A (alpha-Gal A). This enzyme is responsible for breaking down glycolipids such as globotriaosylceramide and its deacylated derivative, globotriaosylsphingosine (LysoGb3). More...
08 Sep 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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