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BioResearch

Image: A permissive captor A computer rendering depicts a GroEL protein hunting down an Aβ protein. Four complementary styles of nuclear magnetic resonance spectroscopy contributed to an understanding of the protein-to-protein interaction (Photo courtesy of Fawzi lab at Brown University).

NMR Innovation Offers Insights into Protein Interaction

By taking a novel approach to nuclear magnetic resonance spectroscopy, scientists have been able to resolve a key interaction between two proteins that could never be seen before. More...
17 Jul 2013

A Novel Cellular Thermal Shift Assay Monitors Intracellular Drug Binding

A team has shown that an advanced thermal shift assay could be exploited by drug developers as a tool for the validation and optimization of correctly targeted drug binding. More...
17 Jul 2013

Disrupted Micronuclei Cited as Potential Non-Small-Cell Lung Cancer Biomarkers

Cancer researchers have found that collapse of the nuclear membrane that surrounds micronuclei may allow these damaged segments of DNA to reenter the cell's genetic material with possible cancer-causing consequences. More...
16 Jul 2013
Image: Agar/PAM DN hydrogels show extraordinary mechanical and free-shapeable properties: (a) bending; (b) knotting; (c) compression; (d) (stretching); (e) hexagon; (f) teddy bear gel under compression; and (g) teddy bear gel after force release (Photo courtesy of Qiang Chen and Chao Zhao).

Hydrogels Assessed for Biomedical Uses

Scientists are studying hydrogel, a hydrophilic polymer chain with similar flexibility to natural tissue, for new biomedical uses. More...
16 Jul 2013
Image: Structures of the adenovirus proteinase in inactive form (turquoise) and activated (yellow) by binding of a cofactor (beige), in association with a promising inhibitor compound identified in this research (circular "ball and stick" molecule). In the inactive form, left, the inhibitor blocks the "pocket" into which the cofactor binds, thus preventing the enzyme from becoming active. In the fully activated enzyme, right, the inhibitor binds in the now-exposed protein-cleaving "active site," thus blocking the enzyme's protein-cleaving ability. The fact that this inhibitor works to disable the proteinase in two different ways at two different sites increases the chance that drugs based on this compound will be successful at fighting adenovirus infection. It also makes it less likely that adenovirus will develop resistance to such drugs (Photo courtesy of Brookhaven National Laboratory).

Computational Modeling Yields Potential Anti-Adenovirus Drugs

Advanced computational modeling was used to identify drug candidates capable of preventing replication of all serotypes of adenovirus. More...
15 Jul 2013
Image: Molecular structures of amyloid oligomers and amyloid fibers (Photo courtesy of the University of California, Los Angeles).

Analysis Reveals Detailed Structural Features of Amyloid Oligomers

Advanced analytical analysis of amyloid-beta42 oligomers has yielded insights into the structure of these oligomers that helps to explain the mechanism behind the process of oligomerization and the reasons for their molecular toxicity. More...
15 Jul 2013

Human Clinical Trial Shows Stem Cell Therapy Hastens Bone Repair

Treatment of fractures of the pelvic bones with stem cells halved recovery time in a clinical study conducted over the past four years. More...
11 Jul 2013
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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