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BioResearch

Image: Human EPS cells (green) can be detected in both the embryonic part (left) and extra-embryonic parts (placenta and yolk sac, right) of a mouse embryo (Photo courtesy of the Salk Institute for Biological Studies).

New Chemical Cocktail Enables Study of Totipotent Stem Cells

A team of developmental molecular biologists has formulated a chemical cocktail that enables the derivation of stem cells with unique functional and molecular features from mice and humans including the ability to maintain a state of totipotency that allows them to develop into extra-embryonic tissues such as placenta. More...
19 Apr 2017
Image: Crystal structures of Mtb RNAP bound to rifampin (left) and Mtb RNAP bound to an AAP (right) show the Mtb RNAP interactions. Gray ribbons, Mtb RNAP backbone; gray, cyan, and green sticks, Mtb RNAP, rifampin, and AAP carbon atoms; red and blue sticks, oxygen and nitrogen atoms; green mesh, mFo-Fc electron density omit map; BH, Mtb RNAP bridge helix (Photo courtesy of Wei Lin and Richard H. Ebright, Rutgers University).

X-Ray Crystallography Findings Aid Discovery of New Drugs

Sensitive X-ray crystallography techniques were used to determine the three-dimensional (3D) molecular structure of the Mycobacterium tuberculosis enzyme RNA polymerase (Mtb RNAP) alone and when bound to the present first-line anti-tuberculosis drug rifampin. More...
18 Apr 2017
Image: Three copies of chromosome 21 characterize the karyotype for trisomy Down syndrome (Photo courtesy of Wikimedia Commons).

Induced Pluripotent Stem Cells Recovered from Urine

Urine from individuals with Down syndrome has been utilized as a source of cells, which researchers first transformed into stem cells and then induced to mature into neurons and heart cells. More...
14 Apr 2017
Image: The structure of Focal adhesion kinase (FAK) (Photo courtesy of Wikimedia Commons).

Cancer Growth Influenced by Myosin and FAK Protein Interaction

A team of cancer researchers has found that the interaction between the myosin and FAK (Focal adhesion kinase) proteins is critical to the ability of cancer cells to grow and spread to sites distant from that of the primary tumor. More...
13 Apr 2017
Image: The Crystal structure of PCSK9 (proprotein convertase subtilisin/kexin type 9) (Photo courtesy of Wikimedia Commons).

Cholesterol-Lowering Small RNA Drug Shows Promise in Early Trial

Results of a phase II, multicenter, double-blind, placebo-controlled, multiple-ascending-dose clinical trial confirmed that the experimental small interfering RNA (siRNA) drug inclisiran was effective for treating patients with elevated LDL cholesterol levels who were at high risk for developing cardiovascular disease. More...
12 Apr 2017
Image: This image shows how the CRISPR surveillance complex is disabled by two copies of anti-CRISPR protein AcrF1 (red) and one AcrF2 (light green). These anti-CRISPRs block access to the CRISPR RNA (green tube) preventing the surveillance complex from scanning and targeting invading viral DNA for destruction (Photo courtesy of The Scripps Research Institute).

Interaction between Proteins Revealed by Cryo-EM Mapping

Cryo-electron microscopy (Cryro-EM) molecular mapping was used to determine how the bacterial gene editing complex CRISPR/Cas9 interacts with viral anti-CRISPR proteins. More...
11 Apr 2017
Image: A clinician using E1-ClipTip electronic pipettes (Photo courtesy of Thermo Fisher Scientific).

Cloud-Based App Enhances Performance of Pipette Line

A cloud-based Internet tool has been released that maximizes the usefulness of a new line of Bluetooth-enabled electronic pipettes. More...
07 Apr 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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