We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
BIO-RAD LABORATORIES

Download Mobile App




Noninvasive Biomarker Tests Could Eliminate Painful Liver Biopsies

By LabMedica International staff writers
Posted on 08 Sep 2023
Print article
Image: Noninvasive biomarker tests could be alternatives to painful liver biopsies (Photo courtesy of 123RF)
Image: Noninvasive biomarker tests could be alternatives to painful liver biopsies (Photo courtesy of 123RF)

Metabolic dysfunction-associated steatohepatitis (MASH), previously known as NASH, is a severe illness. Once the liver begins to scar, the risk of cirrhosis, liver cancer, and death significantly increases. Unfortunately, symptoms of MASH often do not appear until the disease reaches its advanced stages, typically when cirrhosis has developed. Currently, the sole method to diagnose MASH in patients is through liver biopsies. However, this approach offers insights from only a small portion of the liver and fails to provide an accurate overall assessment of the patient's condition. Liver biopsies are also painful, invasive, and expensive for patients. Despite some companies developing blood and imaging biomarker tests, none have met the stringent requirements for FDA regulatory approval. Now, a consortium dedicated to investigating noninvasive tests for liver disease has achieved a significant milestone by demonstrating the effectiveness of five such tests, moving closer to regulatory approval.

The research to evaluate blood and imaging biomarker tests for liver disease is part of NIMBLE – the Noninvasive Biomarkers of Metabolic Liver Disease project – was led by the Virginia Commonwealth University (VCU, Richmond, VA, USA). The NIMBLE biomarker tests were rigorously compared to established measures, including the FIB-4 index used to assess liver health. Any biomarker test that matched or exceeded the performance of existing lab tests was assessed for its potential use in diagnosing MASH and related conditions. Over 1,000 patients participated in this research. These five biomarker tests hold promise for diagnosing MASH and related conditions, providing a noninvasive alternative to liver biopsies. This development is expected to encourage patient participation in future clinical trials, which would otherwise necessitate invasive liver biopsies. Additionally, the use of noninvasive blood tests could significantly reduce the cost of conducting such studies, thus fostering greater interest in drug development. Equally important, these tests could be easily administered in a doctor's office.

“This brings us a step closer to having simple blood-based tests that can be ordered virtually in any clinical setting and will provide access to care to patients,” said Arun Sanyal, M.D., a professor at the VCU School of Medicine. “Such a step will facilitate our ability to identify those most at risk of outcomes and target them for therapy. It will also serve as a foundation for prognostic, disease monitoring and treatment-response biomarker development.”

Related Links:
VCU 

New
Platinum Member
Flu SARS-CoV-2 Combo Test
OSOM® Flu SARS-CoV-2 Combo Test
Magnetic Bead Separation Modules
MAG and HEATMAG
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Automatic Nucleic Acid Extractor
GeneRotex 24

Print article

Channels

Clinical Chemistry

view channel
Image: The new ADLM guidance will help healthcare professionals navigate respiratory virus testing in a post-COVID world (Photo courtesy of 123RF)

New ADLM Guidance Provides Expert Recommendations on Clinical Testing For Respiratory Viral Infections

Respiratory tract infections, predominantly caused by viral pathogens, are a common reason for healthcare visits. Accurate and swift diagnosis of these infections is essential for optimal patient management.... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Microbiology

view channel
Image: The POC PCR test shortens time for STI test results (Photo courtesy of Visby Medical)

POC STI Test Shortens Time from ED Arrival to Test Results

In a 2024 sexually transmitted infections (STIs) surveillance report by the World Health Organization (WHO), over 2.5 million cases were recorded, alongside a rise in the inappropriate use of antibiotics... Read more

Industry

view channel
Image: For 46 years, Roche and Hitachi have collaborated to deliver innovative diagnostic solutions (Photo courtesy of Roche)

Roche and Hitachi High-Tech Extend 46-Year Partnership for Breakthroughs in Diagnostic Testing

Roche (Basel, Switzerland) and Hitachi High-Tech (Tokyo, Japan) have renewed their collaboration agreement, committing to a further 10 years of partnership. This extension brings together their long-standing... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.