We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Octopus Group

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Urine-Based Molecular Test Detects Bladder Cancer Quickly and Accurately

By LabMedica International staff writers
Posted on 14 Mar 2023
Print article
Image: Researchers have developed a novel urine-based test for the non-invasive detection of bladder cancer (Photo courtesy of Nonacus)
Image: Researchers have developed a novel urine-based test for the non-invasive detection of bladder cancer (Photo courtesy of Nonacus)

Flexible cystoscopy, an invasive procedure involving the insertion of a camera into the bladder, is currently the main technique used to identify bladder cancer tumors. However, this process can be uncomfortable and expensive for patients, and the majority of these cystoscopies result in no abnormalities or malignancies being detected. Now, a new urine-based molecular test can rapidly and precisely detect bladder cancer, thereby streamlining diagnosis and minimizing the necessity for invasive procedures like cystoscopies.

A collaboration between the University of Birmingham (Birmingham, UK) researchers and liquid biopsy cancer detection and screening company Nonacus (Birmingham, UK) has resulted in a novel test for the non-invasive detection of bladder cancer. The GALEAS Bladder from Nonacus is a non-invasive, urine-based diagnostic test designed to provide a sample-to-report molecular triage for patients exhibiting symptoms of hematuria (blood in urine). The urine-based molecular biomarker provides a highly sensitive test that enables the rapid and precise detection of bladder cancer, thus enhancing diagnosis and eliminating the need for invasive cystoscopies.

The test combines highly sensitive liquid biopsy technology with a panel of biomarkers to detect the presence of bladder cancer by locating DNA from tumor cells in urine. The biomarker panel has been validated by the researchers in more than 600 patient samples from three UK clinical cohorts. Their analysis has shown the test to have a high diagnostic accuracy (sensitivity >90%, specificity >85%) across all grades and stages of bladder cancer. The test could potentially work across the entire bladder cancer patient pathway, reducing dependence on invasive cystoscopy and expensive imaging for non-muscle-invasive bladder cancer surveillance and minimal residual disease monitoring, as well as triage for hematuria.

“We are very excited to launch GALEAS Bladder,” said Chis Sale, CEO of Nonacus. “We are striving to develop a suite of meaningful non-invasive tools that can have real impact on the diagnosis and treatment of patients with suspected cancer. GALEAS Bladder represents the first in this pipeline, helping to improve patients' lives and reducing the burden of cystoscopy on overstretched clinics.”

Related Links:
University of Birmingham 

Gold Supplier
Automated Electrolyte Analyzer
Gold Supplier
Cerebral Spinal Fluid Control
Multichem CSF
POC Single-Use IVD Test
i-STAT CHEM8+ Cartridge

Print article


Clinical Chem.

view channel
Image: Brief schematic diagram of the detection principle and method (Photo courtesy of CAS)

Rapid, Non-Invasive Method Diagnoses Type 2 Diabetes by Sniffing Urinary Acetone

Over 90% of diabetes cases are attributed to Type 2 diabetes (T2D), a prevalent metabolic condition that is expected to impact 380 million individuals globally by 2025. Despite being highly accurate, the... Read more


view channel
Image: A genetic test could guide the use of cancer chemotherapy (Photo courtesy of Pexels)

Genetic Test Predicts Whether Bowel Cancer Patients Can Benefit From Chemotherapy

Late-stage bowel cancer patients usually undergo a series of chemotherapies and targeted medicines for cancer treatment. However, the responses to the last-line chemotherapy treatment trifluridine/tipiracil... Read more


view channel
Image: Sampling a single stool using multiple PCR panels can identify more pathogens rapidly (Photo courtesy of Pexels)

PCR Panels for Acute GI Infections Can Lower Costs, Hospitalization and Antibiotic Use

Acute gastroenteritis impacts adults across all age groups and incurs enormous healthcare expenses. Now, a new study comprising 40,000 hospital visits across various geographic locations has revealed that... Read more


view channel
Image: Artificial intelligence predicts genetics of cancerous brain tumors in under 90 seconds (Photo courtesy of Michigan Medicine)

AI-Based Diagnostic Screening System Predicts Genetics of Cancerous Brain Tumors in 90 Seconds

The diagnosis and treatment of gliomas increasingly rely on molecular classification, as surgical benefits and risks vary depending on a patient's genetic makeup. Complete removal of the tumor can extend... Read more


view channel
Image: Live view of non-fluorescent specimens using the glowscope frame (Photo courtesy of Winona State University)

Device Converts Smartphone into Fluorescence Microscope for Just USD 50

Fluorescence microscopes are utilized to examine specimens labeled with fluorescent stains or expressing fluorescent proteins, like those tagged with green fluorescent protein. However, since these microscopes... Read more


view channel
Image: Roche and Lilly will collaborate on the development of Roche Diagnostics’ Elecsys Amyloid Plasma Panel (Photo courtesy of Roche)

Roche and Eli Lilly Collaborate on Innovative Blood Test for Early Diagnosis of Alzheimer's

Presently, obstacles to timely and precise diagnosis of Alzheimer's disease exist globally, resulting in as many as 75% of individuals exhibiting symptoms but lacking a formal diagnosis.... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.