We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Octopus Group

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Single Blood Test Detects Various Tumor Types Less Invasively Than Tissue Biopsy

By LabMedica International staff writers
Posted on 06 Mar 2023
Print article
Image: Researchers have developed a liquid biopsy test for pediatric solid tumors (Photo courtesy of Pexels)
Image: Researchers have developed a liquid biopsy test for pediatric solid tumors (Photo courtesy of Pexels)

Around 40% of childhood cancers are pediatric solid tumors. Although pediatric cancer is uncommon, children can develop various tumor types in different body parts, making differential diagnosis difficult. Now, a newly developed liquid biopsy for solid tumors could be highly beneficial in cases where surgery or a tissue biopsy is not possible, potentially enabling more targeted diagnoses.

Pediatric tumors and adult tumors exhibit different genetic makeups, necessitating the development of specific tests for the former. Adult tumors usually result from mutations or sequence-based changes in a gene, resulting in the development of liquid biopsy tests that specifically identify such mutations. However, pediatric tumors caused by mutations are less common. Instead, children's tumors tend to be characterized by copy number changes- having extra or losing copies of one or more genes- or rearrangements of genes resulting in gene fusions. For their research study, investigators at Children’s Hospital Los Angeles (Los Angeles, CA, USA) combined a technique known as Low-Pass Whole Genome Sequencing (LP-WGS) with targeted sequencing of cell-free DNA from plasma to detect copy number changes, as well as mutations and gene fusions, which are typical of pediatric solid tumors. Importantly, the study required a much smaller volume of sample as compared to that required for liquid biopsy studies in adults. The smaller blood volume in an infant or young child required the assays to be scaled down in order to adjust for this difference.

In November 2022, the initial version of the test was released, enabling the evaluation of chromosomal copy number changes in blood samples, cerebrospinal fluid, and the aqueous humor of the eye to support clinical diagnoses of patients with solid tumors, retinoblastoma, and brain tumors, respectively. The upcoming version of the clinical assay, estimated for release in approximately six months, will include the detection of gene fusions and mutations. These liquid biopsy-based genetic tests will add to the CHLA-developed OncoKids cancer panel, a next-generation sequencing-based assay to detect changes in DNA or RNA related to pediatric leukemias, brain and solid tumors; the CHLA Cancer Predisposition Panel; RNAseq for cancer, a transcriptome-based assay using RNA sequencing; VMD4Kids, a panel for vascular and mosaic disorders; as well as methylation array-based profiling for pediatric brain tumors.

“This is one of the first clinically validated liquid biopsy tests to be launched at a pediatric academic medical center,” said Jaclyn Biegel, PhD, Chief of Genomic Medicine and Director of the Center for Personalized Medicine at CHLA.

“We created a test that may be helpful in making a diagnosis, determining prognosis, and potentially identifying an effective therapy for children with solid tumors,” added Fariba Navid, MD, Medical Director of Clinical Research in the Cancer and Blood Disease Institute at CHLA.

Related Links:
Children’s Hospital Los Angeles

Gold Supplier
Hematology Workflow Solution
Silver Supplier
Deepwell Plates
Accumax Deepwell Plates
Syphilis Ab Assay
EIAgen Syphilis Ab Kit
Rapid HBsAg Immunoassay

Print article


Clinical Chem.

view channel
Image: Brief schematic diagram of the detection principle and method (Photo courtesy of CAS)

Rapid, Non-Invasive Method Diagnoses Type 2 Diabetes by Sniffing Urinary Acetone

Over 90% of diabetes cases are attributed to Type 2 diabetes (T2D), a prevalent metabolic condition that is expected to impact 380 million individuals globally by 2025. Despite being highly accurate, the... Read more


view channel
Image: A genetic test could guide the use of cancer chemotherapy (Photo courtesy of Pexels)

Genetic Test Predicts Whether Bowel Cancer Patients Can Benefit From Chemotherapy

Late-stage bowel cancer patients usually undergo a series of chemotherapies and targeted medicines for cancer treatment. However, the responses to the last-line chemotherapy treatment trifluridine/tipiracil... Read more


view channel
Image: Sampling a single stool using multiple PCR panels can identify more pathogens rapidly (Photo courtesy of Pexels)

PCR Panels for Acute GI Infections Can Lower Costs, Hospitalization and Antibiotic Use

Acute gastroenteritis impacts adults across all age groups and incurs enormous healthcare expenses. Now, a new study comprising 40,000 hospital visits across various geographic locations has revealed that... Read more


view channel
Image: Artificial intelligence predicts genetics of cancerous brain tumors in under 90 seconds (Photo courtesy of Michigan Medicine)

AI-Based Diagnostic Screening System Predicts Genetics of Cancerous Brain Tumors in 90 Seconds

The diagnosis and treatment of gliomas increasingly rely on molecular classification, as surgical benefits and risks vary depending on a patient's genetic makeup. Complete removal of the tumor can extend... Read more


view channel
Image: Live view of non-fluorescent specimens using the glowscope frame (Photo courtesy of Winona State University)

Device Converts Smartphone into Fluorescence Microscope for Just USD 50

Fluorescence microscopes are utilized to examine specimens labeled with fluorescent stains or expressing fluorescent proteins, like those tagged with green fluorescent protein. However, since these microscopes... Read more


view channel
Image: Roche and Lilly will collaborate on the development of Roche Diagnostics’ Elecsys Amyloid Plasma Panel (Photo courtesy of Roche)

Roche and Eli Lilly Collaborate on Innovative Blood Test for Early Diagnosis of Alzheimer's

Presently, obstacles to timely and precise diagnosis of Alzheimer's disease exist globally, resulting in as many as 75% of individuals exhibiting symptoms but lacking a formal diagnosis.... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.