We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Octopus Group

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Nanotechnology-Based Blood Test Could Revolutionize Prostate Cancer Diagnosis

By LabMedica International staff writers
Posted on 06 Feb 2023
Print article
Image: The new blood test will help optimize treatment for prostate cancer patients (Photo courtesy of Pexels)
Image: The new blood test will help optimize treatment for prostate cancer patients (Photo courtesy of Pexels)

Cancer of the prostate is the most common cancer and second-leading cause of cancer death among men in the U.S. About 30% of post-surgical patients who get their prostate, a walnut-sized gland just below the bladder, removed can see an increase in prostate-specific antigen (PSA) levels in their blood that can also indicate cancer recurrence. In case a remnant of the cancer is left behind in the prostate bed, where the prostate gland once was, focused radiation therapy can be used to cure the disease or delay progression, although that treatment comes with its own risks. In patients with microscopic cancer deposits spread outside their prostate area, focused radiation treatment cannot prevent disease progression. Even the most advanced imaging cannot detect these deposits, called micro-metastases. Now, researchers have developed a new nanotechnology-based test that can detect and profile prostate cancers - even in microscopic amounts. The “liquid biopsy” test can help patients avoid unnecessary treatment-related side effects and direct them instead to effective therapies that could extend their life span.

The test developed by investigators at Cedars-Sinai (Los Angeles, CA, USA) isolates and characterizes extracellular vesicles, also called EVs, from blood samples. EVs are microscopic packets of protein and genetic material that are shed by cells. The EV Digital Scoring Assay can pull these EV packets from the blood with unprecedented efficiency and analyze them faster than any available test. For the study, the investigators tested blood samples from 40 patients with prostate cancer and found that the test could distinguish cancer localized to the prostate from cancer that had spread to other parts of the body. The investigators were also able to detect microscopic cancer deposits, or micro-metastases, using the EV test.

The test can be used to help patients who have their prostate gland removed and later see increased PSA levels in their blood, according to the investigators. The test could also be adapted to guide treatment as prostate cancer therapies become more targeted at the molecular level, ultimately extending patients’ lives. The investigators are now working to further refine the test so that it can be studied in greater detail.

“This research will revolutionize the liquid biopsy in prostate cancer,” said Edwin Posadas, MD, medical director of the Urologic Oncology Program and co-director of the Experimental Therapeutics Program in Cedars-Sinai Cancer. “The test is fast, minimally invasive and cost-effective, and opens up a new suite of tools that will help us optimize treatment and quality of life for prostate cancer patients.”

Related Links:

Gold Supplier
COVID-19 Antigen Self-Test
Panbio COVID-19 Antigen Self-Test
Free Triiodothyronine (fT3) Rapid Test
Finecare fT3 Rapid Quantitative Test
Platinum Supplier
Automatic Nucleic Acid Extractor
GeneFlex 16n
Laboratory QC Software
Qualis Interlab

Print article


Clinical Chem.

view channel
Image: Brief schematic diagram of the detection principle and method (Photo courtesy of CAS)

Rapid, Non-Invasive Method Diagnoses Type 2 Diabetes by Sniffing Urinary Acetone

Over 90% of diabetes cases are attributed to Type 2 diabetes (T2D), a prevalent metabolic condition that is expected to impact 380 million individuals globally by 2025. Despite being highly accurate, the... Read more


view channel
Image: A genetic test could guide the use of cancer chemotherapy (Photo courtesy of Pexels)

Genetic Test Predicts Whether Bowel Cancer Patients Can Benefit From Chemotherapy

Late-stage bowel cancer patients usually undergo a series of chemotherapies and targeted medicines for cancer treatment. However, the responses to the last-line chemotherapy treatment trifluridine/tipiracil... Read more


view channel
Image: Sampling a single stool using multiple PCR panels can identify more pathogens rapidly (Photo courtesy of Pexels)

PCR Panels for Acute GI Infections Can Lower Costs, Hospitalization and Antibiotic Use

Acute gastroenteritis impacts adults across all age groups and incurs enormous healthcare expenses. Now, a new study comprising 40,000 hospital visits across various geographic locations has revealed that... Read more


view channel
Image: Artificial intelligence predicts genetics of cancerous brain tumors in under 90 seconds (Photo courtesy of Michigan Medicine)

AI-Based Diagnostic Screening System Predicts Genetics of Cancerous Brain Tumors in 90 Seconds

The diagnosis and treatment of gliomas increasingly rely on molecular classification, as surgical benefits and risks vary depending on a patient's genetic makeup. Complete removal of the tumor can extend... Read more


view channel
Image: Live view of non-fluorescent specimens using the glowscope frame (Photo courtesy of Winona State University)

Device Converts Smartphone into Fluorescence Microscope for Just USD 50

Fluorescence microscopes are utilized to examine specimens labeled with fluorescent stains or expressing fluorescent proteins, like those tagged with green fluorescent protein. However, since these microscopes... Read more


view channel
Image: Roche and Lilly will collaborate on the development of Roche Diagnostics’ Elecsys Amyloid Plasma Panel (Photo courtesy of Roche)

Roche and Eli Lilly Collaborate on Innovative Blood Test for Early Diagnosis of Alzheimer's

Presently, obstacles to timely and precise diagnosis of Alzheimer's disease exist globally, resulting in as many as 75% of individuals exhibiting symptoms but lacking a formal diagnosis.... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.