We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




根据糖代谢的变化诊断肝癌

By LabMedica International staff writers
Posted on 13 Jul 2016
基因表达的改变导致癌细胞代谢果糖的方式不同于健康细胞,因而可作为诊断肝癌的新生物标记物。

人体摄入的果糖主要在肝脏内代谢,现在已经证明,相较正常肝细胞,肝细胞癌(HCC)细胞的果糖代谢率和活性氧水平显著降低。

美国德克萨斯大学MD安德森癌症中心的科学家及其同事发现,肝肿瘤细胞内果糖代谢率的降低是由果糖代谢酶(KHK)基因的异常可变剪接引起的。这导致人体表达多种名为KHK-A的基因产物的表达,失去处理果糖的能力。科研小组发现KHK-A的蛋白激酶活性促进了肿瘤细胞DNA和核糖核酸(RNA)的合成,且刚发现的KHK-A对于肝脏肿瘤的形成至关重要。激酶使细胞能够传输磷酸基,对产生能量和调控蛋白质至关重要。

科研小组发现KHK-A起到蛋白质激酶的作用,磷酸化并激活磷酸核糖焦磷酸合成酶1 (PRPS1),促进依赖戊糖磷酸途径的全程核酸合成和肝细胞癌的形成。此外,HCC样本中V-Myc禽骨髓细胞瘤病毒癌基因同源物(c-Myc)、核内不均一核糖核蛋白H1/2 (hnRNPH1/2)以及KHK-A表达水平和PRPS1 Thr225磷酸化水平彼此相关联,并与HCC预后不良有关。

该研究的论文发表于2016年4月18日的《自然》杂志《细胞生物学》分册。作者总结说,他们发现了HCC细胞与正常肝细胞果糖代谢率不同的重要深层机理,并表明KHK-A蛋白激酶活性对于促进全程核酸合成和肝细胞癌形成的重要作用。论文的资深作者、神经肿瘤学教授Zhimin Lu博士说:“我们相信这一蛋白激酶活性可用作治疗肝肿瘤的目标。我们的研究揭示了肝脏和肝肿瘤细胞如何利用果糖的重要深层机理,表明KHK-A蛋白对于刺激肿瘤形成的重要作用。”

Related Links:
德克萨斯大学MD安德森癌症中心

Gold Member
Quality Control Material
iPLEX Pro Exome QC Panel
New
Gold Member
Neonatal Heel Incision Device
Tenderfoot
New
HPV Molecular Test
BD Onclarity HPV Assay
New
Food Allergy Screening ELISA Kit
Allerquant 14G B ELISA
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Clinical Chemistry

view channel
Image: Study results show blood protein levels change markedly in childhood and adolescence, with sex differences increasing with age (photo credit: Adobe Stock)

Proteomic Data Underscore Need for Age-Specific Pediatric Reference Ranges

Serum proteins underpin many routine tests used to detect inflammation, hormonal imbalance, cardiovascular disease, and metabolic disorders. Yet pediatric interpretation often relies on adult reference... Read more

Pathology

view channel
Image: Study flowchart. This study developed a multimodal artificial intelligence framework to predict PIK3CA mutations in breast cancer (Jiaxian Miao et al., Cancer Biol Med 23(3): 430–450 (2026). DOI: 10.20892/j.issn.2095-3941.2025.0771)

Multimodal AI Tool Predicts Genetic Alterations to Guide Breast Cancer Treatment

PIK3CA mutations are key biomarkers for selecting phosphoinositide 3-kinase (PI3K)–targeted therapies in breast cancer, yet access to molecular testing can be inconsistent and costly. Conventional polymerase... Read more
Copyright © 2000-2026 Globetech Media. All rights reserved.