DNA Analysis Systems Reduce DNA Input and Increase Sample Throughput

They offer enhanced signal discrimination and a new single nucleotide polymorphism (SNP) algorithm.

Launched by Illumina's (San Diego, CA, USA) microarray business, the two new products are on the Human1M-Duo beadchip and contain markers for more than one million diverse genetic variants, all of which can be used for both whole-genome genotyping and copy number variation (CNV) analysis.

In addition to Human1M single-sample BeadChip, Illumina's new Human1M-Duo features can identify disease-associated SNPs and intelligently select high-density SNPs in coding regions of the genome. The Human1M-Duo also provides the highest available power to detect SNPs associated with diseases and the least number of large gaps for the identification of CNVs.
The Infinium HD Human1M-Duo (two samples/chip) and the Human610-Quad (four samples/chip), feature up to 2.3 million single nucleotide polymorphisms (SNPs) per beadchip. First customer shipments of the Human610-Quad and Human1M-Duo beadchips are expected in the first and second quarters of 2008, respectively.

The four-sample format of the Human610-Quad beadchip provides customers with a significant increase in sample throughput and reduced handling in the lab. Built upon the content of Illumina's broadly adopted HumanHap550 beadchip, the Human610-Quad beadchip has 550,000 SNPs plus an additional 60,000 genetic markers per sample. Both the Infinium HD Human1M-Duo and Human610-Quad beadchips include high-value, CNV content developed in conjunction with deCODE genetics, only found on Illumina arrays.

"The Human1M-Duo and Human610-Quad beadchips provide our customers with significant advances, including increased sample throughput, lower input sample volume, and improvements to the Infinium assay that enhance overall system performance. Concurrent with the development of these new array products, Illumina has implemented new decoding instruments into its operations that will effectively double Illumina's array manufacturing capacity over the next several quarters,” said John Stuelpnagel, senior vice president, COO, and general manager of Illumina's Microarray Business.

Illumina's genotyping solutions offer a flexible beadchip design and high-density architecture. Infinium HD products provide a powerful complement to Illumina's genotyping offering, which includes Infinium II, iSelect Infinium, GoldenGate, and VeraCode genotyping products.


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