We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Plasma Metabolite Profile and Gut Microbiota Connected to Obesity

By LabMedica International staff writers
Posted on 14 Mar 2018
Print article
Image: Liquid chromatography-mass spectrometry used for targeted profiling of plasma metabolites (Photo courtesy of McGill University).
Image: Liquid chromatography-mass spectrometry used for targeted profiling of plasma metabolites (Photo courtesy of McGill University).
A new link has been discovered between gut bacteria and obesity. It has been found that certain amino acids in the blood can be connected to both obesity and the composition of the gut microbiome.

Emerging evidence has related the gut microbiome and circulating metabolites to human obesity. Gut microbiota is responsible for several metabolic functions and altered plasma metabolome may reflect differences in the gut microbiome.

Scientists at Lund University (Malmö, Sweden) analyzed blood plasma and stool samples from participants in the Malmö Offspring Study (MOS). Targeted profiling of 48 plasma metabolites was performed in a population of 920 Swedish adults (mean age 39 years, 53% were women) using targeted liquid chromatography-mass spectrometry. Gut microbiota was analyzed by sequencing of the16S rRNA gene (V1-V3 region) in fecal samples of 674 study participants.

The scientists reported that body mass index (BMI) was associated with 19 metabolites, of which glutamate provided the strongest direct association. By orthogonal partial least squares regression a metabolite principal component predictive of BMI was constructed (PCBMI). In addition to glutamate, PCBMI was dominated by branched chain amino acids (BCAA) and related metabolites. Four gut microbiota genera in the Lachnospiraceae family: L. blautia, L. dorea, L. ruminococcus and SHA-98) were associated with both BMI and PCBMI . When simultaneously regressing the PCBMI and the metabolite associated gut bacteria against BMI, only PCBMI remained significant.

Marju Orho-Melander, PhD, a professor of genetic epidemiology and senior investigator of the study, said, “The differences in BMI were largely explained by the differences in the levels of glutamate and BCAA. This indicates that the metabolites and gut bacteria interact, rather than being independent of each other. This means that future studies should focus more on how the composition of gut bacteria can be modified to reduce the risk of obesity and associated metabolic diseases and cardiovascular disease.” The study was published on February 1, 2018, in The Journal of Clinical Endocrinology & Metabolism.

Related Links:
Lund University

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
POCT Fluorescent Immunoassay Analyzer
FIA Go
New
Gold Member
Systemic Autoimmune Testing Assay
BioPlex 2200 ANA Screen with MDSS

Print article

Channels

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.