Antibody Treatment Slows Lung Cancer Growth in Mouse Model

It also increases peripheral vascular resistance, which in turn increases arterial blood pressure. It plays a key role in homeostasis, by the regulation of water, glucose, and salts in the blood.

The investigators treated a group of SCLC mice with MAG-1, a mouse monoclonal antibody specific for the pro-vasopressin C-terminal moiety. They reported in the February 14, 2014, online edition of the journal Frontiers in Oncology that the antibody attached to SCLC cells and it was internalized. Antibody treatment decreased the rate of increase in tumor size by half, and doubling time by about three-fold. Normal tissues seemed not to be affected.

"We are developing methods of antibody-targeted treatment for recurrent small-cell lung cancer," said senior author Dr. William G. North, professor of physiology at Dartmouth College. "Targeting with a humanized MAG-1 can likely be effective, especially when given in combination with chemotherapy, for treating a deadly disease for which there is no effective therapy."

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