Roche NimbleGen and Caliper Cooperate to Deliver Automated Pipeline Solution for Next-Generation Sequencing

Hoffmann-La Roche Ltd. (Roche; Basel, Switzerland), a leader in research-focused healthcare and Caliper Life Sciences, Inc. (Hopkinton, MA, USA), a life science technology provider, have signed a collaboration agreement. The purpose of the agreement is the joint development and optimization of automated protocols for Roche's NimbleGen SeqCap EZ Library solution-based capture method for Caliper’s Sciclone NGS Workstation.

The objective of the collaboration is to simplify high-throughput targeted-resequencing workflows by creating automated methods for sequencing library preparation and enrichment of target regions, quantification, and quality control. These methods will enable biomedical researchers worldwide to study human diseases by analyzing large cohorts to discover and confirm genetic variants that contribute to them.

“Roche NimbleGen is committed to providing the research community with innovative and enabling solutions for targeted resequencing,” said Dr. Frank Pitzer, CEO of Roche NimbleGen, Inc. “The continued exponential growth of sequencing throughput and the volume of samples to be analyzed has shifted the bottleneck to sample preparation and process control. By combining our solutions with Caliper’s NGS workstation, the bottlenecks are eliminated, creating the capacity to analyze large cohorts and optimize research efforts.”

“Caliper’s Sciclone NGS Workstation significantly accelerates high throughput sequencing sample preparation and enrichment for numerous sequencing chemistries and workflows,” said Kevin Hrusovsky, president and CEO of Caliper Life Sciences. “Together Caliper and Roche NimbleGen are developing targeted sequencing applications that enable studies that analyze variants across large populations to detect and better understand the causal agents of disease.”

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