We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
Vicotex

Download Mobile App




DNA Mutations Identified in Chemotherapy-Resistant Cancer Cells

By Biotechdaily staff writers
Posted on 17 Apr 2008
The development of chemotherapy resistance was investigated in an in-vitro model of ovarian cancer.

Array comparative genomic hybridization (aCGH), gene expression profiling, and molecular cytogenetic analyses were used for genome profiling in cisplatin-resistant ovarian cancer cells. More...
aCGH detects genomic aberrations not evident by traditional cytogenetic techniques, whereas cytogenetic analysis detects structural changes not apparent by aCGH. Genomic interrogation that applies aCGH, gene expression profiling, and molecular cytogenetic analyses in a parallel fashion yields a much more comprehensive genomic profile to assess the chromosomal abnormalities associated with disease.

Using Agilent (Santa Clara, CA, USA) microarrays, scientists from the division of applied molecular oncology, Ontario Cancer Institute, Princess Margaret Hospital (OCI; Toronto, Canada) analyzed copy number and gene expression concurrently in an in-vitro model of ovarian cancer. The third component of the study included advanced molecular cytogenetic analyses. The results of this multi-front approach to genomic profiling enabled the group to identify relationships between particular genomic aberrations and expressed loci, and to reveal the origin of acquired chromosomal mutations in a drug-resistant cell line.

The study is available online in April 2008, in an early edition of the journal Genes Chromosomes Cancer.


Related Links:
Agilent
Ontario Cancer Institute, Princess Margaret Hospital

Platinum Member
Automated Coagulation Analyzer
Hemolumi H6
New
Gold Member
Platelet Function Analyzer
PL-12
CMV CLIA Diagnostic
CLIA CMV IgA Screen Group
Thyroid Test
Anti-Thyroid EIA Test
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Clinical Chemistry

view channel
Image: Nian Sun has spent years perfecting a device that he believes could change the way diseases are detected. (Photo courtesy of Alyssa Stone/Northeastern University)

Rapid Breath Sensor Detects SARS-CoV-2 from Exhaled Air

Nasal swabs and polymerase chain reaction (PCR) testing have been central to identifying SARS-CoV-2, but they can be uncomfortable, slow, and logistically complex when samples require transport.... Read more

Molecular Diagnostics

view channel
Image: At the MHH Institute of Human Genetics: Prof. Dr. Doris Steinemann, Dr. Bernardus Aldrige Allister and Prof. Dr Monika Golas (from left). (Image Credit: Karin Kaiser/MHH)

Multi-Omics Analysis Identifies Additional Risk Genes in Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer can be difficult to explain genetically, leaving many high-risk families without clear answers. Although 13 established risk genes, including BRCA1 and BRCA2, are routinely... Read more
Copyright © 2000-2026 Globetech Media. All rights reserved.