Mouse Model With p53 Mutations

They reported in the December 17, 2004, issue of Cell that animals with two different p53 mutations developed a variety of cancers that were not seen in either normal control animals or in mice lacking p53.

"The LFS mouse strains, which have been many years in the making, will be extremely valuable in understanding how the common mutations in p53 contribute to tumor formation,” said senior author Dr. Tyler Jacks, professor of biology at the Massachusetts Institute of Technology. "We expect these strains will also help us determine how to specifically treat p53 mutant tumors.”




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