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Immunology

Image: The Roche cobas electro-chemiluminescence immunoassay kit for alpha-fetoprotein (AFP) (Photo courtesy of Toliopoulos Diagnostics).

Plasma HSP90α Levels Used for Detection of Hepatocellular Carcinoma

 Liver cancer is composed mostly of primary liver cancers and secondary liver cancers. Hepatocellular carcinoma (HCC), as the major type of primary liver cancer, is the fifth most common tumor worldwide and the third leading cause of cancer mortality, responsible for 745,500 cancer deaths annually. More...
14 Jan 2020
Image: The ABI PRISM 3500 Genetic Analyzer Platform (Photo courtesy of Applied Biosystems)

Multiplex Nested Polymerase Chain Reaction Developed for Congenital Infections

 Infections are the leading cause of perinatal mortality in low- and middle-income countries, which have a higher prevalence of infections, and are responsible for 50% of infant deaths in the first year of life. Definitive diagnosis of congenital and perinatal infections is largely dependent upon the results of laboratory tests. More...
13 Jan 2020
Image: Examples of negative and positive Chagas Stat-Pak RDT results. From left to right, negative, weakly positive, and strongly positive Stat-Pak results are shown (Photo courtesy of Yves Jackson)

Rapid Diagnostic Tests for Chagas Disease Field Evaluated

 Chagas disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is the neglected tropical disease exerting a highest burden in the Western hemisphere. It is estimated that there are around seven million people affected worldwide, the majority of them living in Latin America where the insect vectors that transmit the infection are endemic. More...
08 Jan 2020
Image: Design of the CareStart G6PD deficiency screening test and interpretation of the results: Panel A, no color change for sample with deficient G6PD enzymatic activity; Panel B, distinct purple color for sample with normal G6PD enzymatic activity (Photo courtesy of Charles Darwin University).

Rapid Diagnostic Test for The Detection of G6PD Deficiency Evaluated

 To reduce the risk of drug-induced hemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the treatment of vivax malaria. More...
07 Jan 2020
Image: The Diagnostic Performance of C6 Enzyme Immunoassay for Lyme Arthritis has been evaluated (Photo courtesy of Lonnie R. Marcum, PT, BSHCA)

Immunoassay May Help Identify Pediatric Lyme Arthritis

 In the USA, Lyme arthritis is the most common feature of late stage infection with the tick-borne spirochete, Borrelia burgdorferi, usually beginning months after the initial tick bite. Patients with Lyme arthritis have intermittent or persistent attacks of joint swelling and pain in one or a few large joints, especially the knee, usually over a period of several years, without prominent systemic manifestations. More...
07 Jan 2020
Image: Schematic diagram of how novel immature natural killer cell subpopulation predicts relapse after cord blood transplantation (CBT) (Photo courtesy of MD Anderson Cancer Center).

Immature Natural Killer Cells Predict Relapse After Cord Blood Transplantation

 Umbilical cord blood transplantation (CBT) has become an accepted alternative treatment of patients with hematologic cancers or other disorders. Many of the disadvantages of CBT, including limited numbers of total nucleated cells, have been dealt with in significant ways, leading to marked reductions in the time to hematopoietic cell recovery. More...
31 Dec 2019
Image: Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations (Photo courtesy of Cornell University)

Immune System Altered in Chronic Fatigue Syndrome

 Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe, chronic, and debilitating disease that can cause a range of symptoms including pain, severe exhaustion, cognitive impairment, and post-exertional malaise, the worsening of symptoms after physical or mental activity. More...
27 Dec 2019
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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