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Molecular Diagnostics

Image: Optimized reaction time for Multiple Cross Displacement Amplification (MCDA-LFB) assay to detect Legionella pneumophila. The best sensitivity was seen when the amplification lasted for 35 minutes (Photo courtesy of Zhejiang Provincial People’s Hospital)

MCDA-LFB Assay Developed for Rapid Detection of Legionnaires’ Disease

Legionella pneumophila is an opportunistic waterborne pathogen of significant public health problems, which can cause serious human respiratory diseases (Legionnaires’ disease). Legionnaires’ disease is characterized by severe lung infection symptoms, including severe pneumonia with a high fatality rate. More...
18 Jan 2022
Image: A chest X-ray showing a tumor in the lung (marked by arrow) (Photo courtesy of Wikimedia Commons)

Tumor Biomarker Panel Improves Identification of Candidates for Lung Cancer Screening

Use of a blood-based tumor biomarker panel in combination with modeling according to results of PLCOm2012 (Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial) significantly improved risk assessment for lung cancer screening. More...
17 Jan 2022
Image: Curian immunofluorescent testing platform (Photo courtesy of Meridian Bioscience, Inc.)

Meridian Receives FDA Clearance for Rapid Fluorescent Immunoassay for Detection of Campylobacter Infection

Meridian Bioscience, Inc. (Cincinnati, OH, USA) has received U.S. Food and Drug Administration (FDA) clearance for its Curian Campy assay developed to be utilized on the Curian immunofluorescent testing platform. More...
14 Jan 2022
Image: QX200 AutoDG ddPCR System and QXDx BCR-ABL %IS Kit (Photo courtesy of Bio-Rad)

ddPCR Developed for BCR-ABL1 Fusion Transcript in B-Lymphoblastic Leukemia

Droplet digital polymerase chain reaction (ddPCR) is a novel polymerase chain reaction (PCR) technique reliant on massive sample partitioning to generate individual reaction chambers (droplets) in which individual amplification targets are detected. More...
12 Jan 2022
Image: The Promega MSI Analysis System V1.2 and the LMR-MSI systems are PCR-based methods for detecting microsatellite instability (MSI) in solid tumors (Photo courtesy of Promega)

Long Mononucleotide Repeat Markers Validated for Microsatellite Instability Detection

Mismatch repair deficiency (dMMR) predicts response to immune checkpoint inhibitor therapy in solid tumors. Long mononucleotide repeat (LMR) markers may improve the interpretation of microsatellite instability (MSI) assays. More...
12 Jan 2022
Image: ProGastro SSCS is a multiplex real time PCR for the detection and differentiation of Salmonella, Shigella, Campylobacter, (C. jejuni and C. coli only, undifferentiated) nucleic acids and Shiga Toxin 1 (stx1) and Shiga Toxin 2 (stx2) genes (Photo courtesy of Hologic)

Commercial RT-PCR Tests Compared to Culture for Bacterial Gastroenteritis

Nucleic acid-based testing (culture-independent diagnostic testing, CIDT) for bacterial gastroenteritis offers three major advantages over culture-based diagnosis: it has better analytical sensitivity, is less labor intensive through automation, and has faster turnaround times. More...
11 Jan 2022
Image: Human prostate specific antigen (PSA) with bound substrate from complex with antibody (Photo courtesy of Wikimedia Commons)

A Novel Lateral Flow Immunoassay System for Determination of Prostate Specific Antigen

A recent paper described the development of a highly portable quantitative screening test for prostate cancer. More...
10 Jan 2022
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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