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BioResearch

Image: Lung cancer cells (green) are cultured together with normal lung cells (red). The triple-antibody combination EGFR, HER2, and HER3 strongly impairs the survival of tumor cells while sparing normal cells (Photo courtesy of Weizmann Institute of Science).

Antibody Cocktail Blocks Growth of Drug-Resistant Lung Tumors in Mouse Model

Cancer researchers developed a cocktail of three monoclonal antibodies that was able to halt drug-resistant tumor growth in a mouse xenograft lung cancer model.  More...
17 Jun 2015

Monoclonal Antibody Blocks Development of Type I Diabetes in Mouse Model

Monoclonal antibody treatment prevented development of type I diabetes in a mouse model of the disease.   More...
17 Jun 2015
Image: In meso in situ serial crystallography (IMISX) equipment that was used to quickly and accurately provide detailed blueprints of protein structure (Photo courtesy of Dr. Martin Caffrey, Trinity College Dublin).

Structure of Integral Membrane Proteins Readily Solved Using an Alternative In Meso In Situ Serial Crystallography Technique

A recent paper discussed the benefits of using synthetic cyclic olefin copolymer plates to replace glass as the base for generation and growth of crystals of membrane and soluble proteins for high-resolution X-ray crystallographic structure determination.   More...
16 Jun 2015

A Drug That Prevents Lung Damage Protects Mice with Influenza Infection

A novel approach for treating infection by the influenza virus focuses on strengthening the small blood vessels in the lung of the victim so they do not leak fluids, which can lead to respiratory failure.  More...
16 Jun 2015
Image: Electron micrograph of bacteriophages attached to a bacterial cell. Phages were used to deliver programmable DNA nuclease to reverse antibiotic resistance and eliminate the transfer of resistance between strains (Photo courtesy of Wikimedia Commons).

Novel Phage Treatment Restores Bacterial Sensitivity to Antibiotics

A novel phage-based genetic strategy has been developed that aims to sensitize bacteria to antibiotics while selectively killing antibiotic-resistant strains.   More...
15 Jun 2015
Image: DNA polymerase forms a homodimeric ring (shown as blue cartoon and surface representation). Each polypeptide chain binds one molecule of griselimycin (red). The optimized compound cyclohexylgriselimycin contains an additional cyclohexane moiety (yellow, shown only for the ligand in the foreground) (Photo courtesy of the Helmholtz Centre for Infection Research).

New Version of Old Drug Shows Promise for Treating Drug-Resistant Tuberculosis

A team of molecular microbiologists has determined the mechanism by which theStreptomyces-derived antibiotic griselimycin blocks the growth of Mycobacterium tuberculosis, the bacterium responsible for causing more than eight million cases of tuberculosis annually on a worldwide basis.  More...
15 Jun 2015
Image: Scanning electron micrograph (20,000x) of a strain of Staphylococcus aureus (Photo courtesy of the CDC - [US] Centers for Disease Control and Prevention).

Chronic Exposure to Bacterial Superantigens Induces Diabetes-Like Symptoms in Rabbit Model

Researchers working with a rabbit model have shown that chronic exposure to the toxin produced by the bacterium Staphylococcus aureus can induce metabolic changes similar to those seen in type II diabetes.  More...
14 Jun 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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