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BioResearch

Image: Schematic representation of HIV DART binding to two distinct antigens simultaneously, redirecting the killer T-cells to destroy HIV-1 infected cells (Photo courtesy of Duke University).

Bi-Specific Antibodies Shown to Clear Latent HIV Infections

Bi-specific antibodies or DARTS have been used to eliminate latent HIV-infection from patient samples by redirecting polyclonal T-cells to specifically engage with and kill HIV-infected cells that display HIV antigens on their cell membranes.  More...
12 Oct 2015
Image: Molecular model of the dystrophin protein (Photo courtesy of Wikimedia Commons).

Novel Gene Therapy Treatment Extends Life of Mice Severely Affected by Muscular Dystrophy

An alternative gene therapy approach was used to successfully treat a mouse model of Duchenne muscular dystrophy.  More...
11 Oct 2015

Sale of Mexican Pharmaceutical Company Expected to Boost Latin American Prescription Drug Market

The sale of a major Mexican pharmaceutical company to an international generic drug corporation is expected to accelerate the growth of the Latin American market for prescription drugs.  More...
11 Oct 2015
Image: Use of catchphrase terms like “breakthrough” and “promising” in public news media presenting new drugs tends to result in incorrect assumptions and conclusions about the meaning and significance of criteria for FDA breakthrough-designated and accelerated-approval drugs (Photo courtesy of Dartmouth Institute).

Words That Inappropriately Enhance Perception of New Drug’s Effectiveness

Researchers have found that using the words “breakthrough” and “promising” in presenting a new drug to the general public often has a dramatic effect on judgment about its effectiveness. The findings are especially relevant for drugs designated by the US Food and Drug Administration as meeting certain criteria.  More...
07 Oct 2015
Image: Micrograph showing immunofluorescence of skin differentiation markers for basal keratinocytes (Photo courtesy of Dr. Russ Carstens, University of Pennsylvania).

Alternate Splicing Proteins Critically Linked to Skin and Organ Development

Two proteins that regulate alternative splicing in epithelial cells have been linked to the proper development of the skin and protective layers that surround other organs in the body.  More...
06 Oct 2015
Image: Trophozoites of Entamoeba histolytica with ingested erythrocytes that appear as dark inclusions in this trichrome stained slide (Photo courtesy of the CDC - [US] Centers for Disease Control and Prevention).

Entamoeba hystolytica Manipulates Host Ion Transport Proteins to Cause Cell Death

A team of molecular microbiologists has found that immunity to infection by the parasitic amoeba Entamoeba hystolytica could be induced in humans by using RNAi technology to block the genes controlling the activity of potassium ion transporter proteins.  More...
06 Oct 2015
Image: representation of a protein (blue), which contains three zinc fingers in complex with DNA (orange). The coordinating amino acid residues and zinc ions (green) are highlighted (Photo courtesy of Wikimedia Commons).

Molecular Sensors Generated by Synthetic Biology Technique Using Intein-Based Protein Splicing

Biotech researchers have used intein-based protein splicing to generate synthetic protein components that are able to detect specific DNA sequences and subsequently trigger a desired intracellular response such as activation of a gene or initiation of a molecular pathway.  More...
05 Oct 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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