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BioResearch

Image: A micrograph of a mouse heart section showing human progenitor cells that formed functional human blood vessels. Purple color signifies human blood vessels, red staining signifies the blood vessels of the mouse that received the human cell implants (Photo courtesy of Dr. Jalees Rehman, University of Illinois).

Progenitor Cells Show Promise for Repairing Heart Attack Damage

Intermediate progenitor cells can be induced to develop into either endothelial cells (the type of cell that lines the walls of blood vessels) or into erythroblasts (the type of cells that mature into red blood cells) depending on the level of the transcription factor SOX17. More...
21 Apr 2017
Image: Circulating white blood cells, commonly referred to as leukocytes (large yellow clusters), can be seen lining an inflamed vessel wall along with leukosomes (small yellow speckles). Leukosomes, designed to mimic white blood cells, go unnoticed as they accumulate at the inflamed vessel (purple background), allowing them to concentrate their therapeutic payload at the target site (Photo courtesy of Houston Methodist Hospital).

Study Explains How Drug Carriers Interact with Immune System

Researchers seeking to develop nanoparticle-based drug delivery systems have determined how a specialized class of nanoparticles called leukosomes avoids immune system response in a mouse model system. More...
20 Apr 2017
Image: Human EPS cells (green) can be detected in both the embryonic part (left) and extra-embryonic parts (placenta and yolk sac, right) of a mouse embryo (Photo courtesy of the Salk Institute for Biological Studies).

New Chemical Cocktail Enables Study of Totipotent Stem Cells

A team of developmental molecular biologists has formulated a chemical cocktail that enables the derivation of stem cells with unique functional and molecular features from mice and humans including the ability to maintain a state of totipotency that allows them to develop into extra-embryonic tissues such as placenta. More...
19 Apr 2017
Image: Crystal structures of Mtb RNAP bound to rifampin (left) and Mtb RNAP bound to an AAP (right) show the Mtb RNAP interactions. Gray ribbons, Mtb RNAP backbone; gray, cyan, and green sticks, Mtb RNAP, rifampin, and AAP carbon atoms; red and blue sticks, oxygen and nitrogen atoms; green mesh, mFo-Fc electron density omit map; BH, Mtb RNAP bridge helix (Photo courtesy of Wei Lin and Richard H. Ebright, Rutgers University).

X-Ray Crystallography Findings Aid Discovery of New Drugs

Sensitive X-ray crystallography techniques were used to determine the three-dimensional (3D) molecular structure of the Mycobacterium tuberculosis enzyme RNA polymerase (Mtb RNAP) alone and when bound to the present first-line anti-tuberculosis drug rifampin. More...
18 Apr 2017
Image: Three copies of chromosome 21 characterize the karyotype for trisomy Down syndrome (Photo courtesy of Wikimedia Commons).

Induced Pluripotent Stem Cells Recovered from Urine

Urine from individuals with Down syndrome has been utilized as a source of cells, which researchers first transformed into stem cells and then induced to mature into neurons and heart cells. More...
14 Apr 2017
Image: The structure of Focal adhesion kinase (FAK) (Photo courtesy of Wikimedia Commons).

Cancer Growth Influenced by Myosin and FAK Protein Interaction

A team of cancer researchers has found that the interaction between the myosin and FAK (Focal adhesion kinase) proteins is critical to the ability of cancer cells to grow and spread to sites distant from that of the primary tumor. More...
13 Apr 2017
Image: The Crystal structure of PCSK9 (proprotein convertase subtilisin/kexin type 9) (Photo courtesy of Wikimedia Commons).

Cholesterol-Lowering Small RNA Drug Shows Promise in Early Trial

Results of a phase II, multicenter, double-blind, placebo-controlled, multiple-ascending-dose clinical trial confirmed that the experimental small interfering RNA (siRNA) drug inclisiran was effective for treating patients with elevated LDL cholesterol levels who were at high risk for developing cardiovascular disease. More...
12 Apr 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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