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Molecular Diagnostics

Image: A visualization of morulae in the cytoplasm of a granulocyte during examination of blood smears is highly suggestive of a diagnosis of Human Granulocytic Anaplasmosis (Photo courtesy of the US Centers for Disease Control and Prevention).

Diagnostic Methods Compared for Human Granulocytic Anaplasmosis

Human granulocytic anaplasmosis (HGA) is a tick-borne intracellular bacterial infection caused by Anaplasma phagocytophilum. The disease is present in North America, Europe, and northern Asia, areas with Ixodes ricinus ticks, the primary vector for transmission to humans. More...
02 May 2019
Image: The blood test by Natera detects breast cancer relapses (Photo courtesy of the University of Leicester).

Personalized Detection of ctDNA Antedates Breast Cancer

Breast cancer is one of the most commonly diagnosed cancers worldwide and the second leading cause of cancer-related deaths in women. The current standard of care for women with primary (non-metastatic) breast cancer is surgery, often followed with adjuvant therapy to eliminate microscopic minimal residual disease (MRD). More...
01 May 2019
Image: The ABI 7900HT Fast Real-Time PCR System (Photo courtesy of Thermo Fisher Scientific).

Novel Genes and Pathways Discovered in Celiac Disease

Celiac disease (CD) is a chronic systemic autoimmune disease that occurs globally in genetically predisposed individuals in response to ingestion of gluten-containing grains. While the pathognomonic damage occurs in the small intestine, clinical manifestations are varied and include both intestinal and extra-intestinal symptoms. More...
01 May 2019
Image: Blood film of a patient with acute myelogenous leukemia defined by presence of more than 90% myeloblasts in blood and/or bone marrow (Photo courtesy of Pathpedia).

Protein Atlas Accelerates Personalized Medicine in Leukemia Patients

Acute myelogenous leukemia is associated with risk factors that are largely unknown and with a heterogeneous response to treatment. Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis. More...
30 Apr 2019
Image: A histopathology of oral cancer: tumor islands can be seen infiltrating the connective tissues deep to the overlying oral epithelium. This carcinoma is moderately differentiated with a non-cohesive invasive pattern (Photo courtesy of University of Sheffield).

Biomarkers of Oral Cancer Discovered

Epigenetics, the non-genetic influences on gene expression, is a powerful mechanism capable of altering gene expression in cancer cells without changes to the DNA sequence, and can cause tumor progression. More...
30 Apr 2019
Image: The Qubit 4 Flurometer is designed to accurately measure DNA, RNA, and protein quantity, and now also RNA integrity and quality, using the highly sensitive Qubit assays (Photo courtesy of Thermo Fisher Scientific).

Human Microbiome Features Stratify Children with IBS

Irritable bowel syndrome (IBS) is a disruptive gastrointestinal condition characterized by bloating, changes in bowel habits, and pain that affects up to 20% of the world's population (children and adults). Increasing evidence indicates that the onset and symptoms of IBS are related to the gut microbiome. More...
30 Apr 2019
Image: The use of WES on adults with liver disease of unknown cause illustrates the potential clinical value of genome rounds in the individual assessment and medical care of patients (Photo courtesy of the Yale School of Medicine / Journal of Hepatology).

Unexplained Liver Disease Diagnosed by Whole-Exome Sequencing

A recent paper promoted the use of whole-exome sequencing (WES) to detect and diagnose cases of unexplained liver disease. More...
29 Apr 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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