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Molecular Diagnostics

Image: Typical or `classical` ALS involves neurons in the brain (upper motor neurons) and in the spinal cord (lower motor neurons) (Photo courtesy of Wikimedia Commons)

An Eight MicroRNA Biomarker Panel for Diagnosis of ALS

A team of neurodegenerative disease researchers has identified eight microRNA sequences from enriched exosome extractions of blood plasma that consistently and significantly differentiate patients with amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) from healthy controls. More...
07 Jul 2020
Image: The Bioanalyzer RNA 6000 Nano assay provides reliable and reproducible characterization of total RNA and mRNA from multiple sample types (Photo courtesy of Agilent Technologies).

RNA Sequencing as Alternative to Immunohistochemistry in Cancer Diagnostics

The conventionally used method for cancer diagnostics relies on immunohistochemical dyeing of tumor tissue sections. It allows detecting the presence and measuring the concentration of marker proteins characterizing malignant growths. The resulting microscope images indicate whether the tumor is malignant and what its molecular type is. This information is crucial for selecting the right therapy. More...
06 Jul 2020
Image: The Chemagic 360 extracts DNA and uses transiently magnetized rods to attract the beads after binding to the nucleic acids (Photo courtesy of PerkinElmer).

Blood Group Locus Contributes to COVID-19 Severity Risk

There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). More...
02 Jul 2020
Image: Variability in prostate cancer–specific multigene panels; genetic testing registry as of August 2019 (Photo courtesy of Saud H. AlDubayan, MD).

Precision Medicine-Based Genetic Testing Developed for Prostate Cancer

Germline testing (GT) is a central feature of prostate cancer (PCA) treatment, management, and hereditary cancer assessment. Critical needs include optimized multigene testing strategies that incorporate evolving genetic data, consistency in GT indications and management, and alternate genetic evaluation models that address the rising demand for genetic services. More...
01 Jul 2020
Image: This image depicts a DNA molecule that is methylated on both strands on the center cytosine. The two white spheres represent methyl groups (Photo courtesy of Wikimedia Commons)

Sensitive and Accurate Cancer Detection Through Analysis of Circulating Free DNA Methylation Patterns

An advanced liquid biopsy method for the detection and diagnosis of various types of cancer is based on the analysis of circulating tumor DNA methylation profiles. More...
30 Jun 2020
Image: Circulating tumor DNA (ctDNA) is found in serum and plasma fractions from blood. The mechanism of ctDNA release is unknown, though apoptosis, necrosis, and active secretion from tumor cells have been hypothesized. Once ctDNA is isolated, it can be sequenced for mutational analysis (Photo courtesy of Wikimedia Commons)

Highly Sensitive Liquid Biopsy Technique Brings Personalized Cancer Monitoring a Step Closer

A modified liquid biopsy method enables detection of circulating tumor DNA (ctDNA) with much greater sensitivity than previously used techniques and demonstrates the potential to revolutionize all aspects of cancer care, from early detection to personalized treatment and monitoring. More...
29 Jun 2020
Image: The MiSeq Next Generation Sequencer is an integrated instrument that performs clonal amplification, genomic DNA sequencing, and data analysis with base calling, alignment, variant calling, and reporting in a single run (Photo courtesy of Illumina).

Gut Microbiome Dysbiosis Characterized in Parkinson’s Disease

Parkinson’s disease (PD) is a common, progressive, and debilitating disease, which currently cannot be prevented or cured. With the exception of rare genetic forms, the cause of PD is unknown. Symptoms start gradually, sometimes starting with a barely noticeable tremor in just one hand. Tremors are common, but the disorder also commonly causes stiffness or slowing of movement. More...
29 Jun 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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