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Clinical Chemistry

Image: The Jasco UV/Vis 530 spectrophotometer (photo courtesy of Jasco Analytical Instruments).

Micro-Method Determines Glutathione in Human Blood

A new colorimetric procedure has been described for the visible-range spectrophotometric analysis of glutathione in microvolumes of blood collected by fingerstick and validated by reliable high-performance liquid chromatography.  More...
27 Aug 2014
Image: Rolling circle replication produces multiple copies of a single circular template (Photo courtesy of Madeleine Price Ball via Wikimedia Commons).

Novel Diagnostic Test Differentiates Type I from Type II Diabetes at an Early Stage

A novel DNA-based diagnostic test enables the early detection of type I diabetes while differentiating patients with type I diabetes from those with the type II form of the disease.   More...
26 Aug 2014
Image: The Vantera Clinical Analyzer offers the technology that has the ability to directly enumerate low-density lipoprotein (LDL) particle numbers (Photo courtesy of LipoScience).

LDL Particle Number Measured Using NMR Clinical Analyzer

Fully-automated high-throughput nuclear magnetic resonance spectroscopy has been developed to enable measurements in a clinical laboratory setting.   More...
25 Aug 2014
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Semiquantitative Urine Dipstick Evaluated for Microalbuminuria Screening

The urine microalbumin test is used as a screening test for the diagnosis of renal complications in diseases, such as diabetic nephropathy, cardiovascular disease, and hypertension.  More...
21 Aug 2014
Image: The Q700 microsonicator (Photo courtesy of Qsonica).

Urinary Biomarker Discovered in Variant Creutzfeldt-Jakob Disease

The misfolded and infectious prion protein that is a marker for variant Creutzfeldt-Jakob disease has been detected in the urine of patients with the disease.  More...
20 Aug 2014
Image: The NanoDrop 2000 Spectrophotometer (Photo courtesy of Thermo Scientific).

Small RNAs in Blood May Reveal Heart Injury

An increase in certain micro ribonucleic acids circulating in the blood are linked with injury to cardiac muscle and these molecules might provide the basis for a more sensitive diagnostic tool than those currently available.  More...
14 Aug 2014

Red Blood Cell Folate Level Is a Biomarker for Risk of Neural Tube Defects

The importance of maintaining high red blood cell levels of folate during pregnancy to reduce risk of neural tube defects was confirmed in a review of results obtained by a large study of expectant mothers in China.  More...
13 Aug 2014
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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