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Clinical Chemistry

Novel Miniature Mass Spectrometer Moves Cocaine Measurement to the Field

A novel device for field testing of cocaine and other drugs comprises a portable mass spectrometer and a system for rapid drying and extracting urine samples.   More...
07 Jul 2014
Image: Histopathology of non-alcoholic fatty liver disease showing the liver with prominent macrovesicular steatosis (Photo courtesy of Nephron).

Liver Values Elevated in Overweight Children with Gene Mutation

Genetic polymorphism has been strongly associated with liver fat content and plasma alanine aminotransferase levels in obese adults and children, but little is known about these relationships in normal weight individuals.  More...
07 Jul 2014
DIASOURCE (A Biovendor Company)
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Ultra-Performance LC-MS System Approved for Clinical Applications in China

An ultra-performance liquid chromatography – mass spectrometry system has been approved by the Chinese Food and Drug Administration as a medical device for routine diagnostic applications and for screening of neonatal metabolites diseases.   More...
03 Jul 2014
Image: The Applied Biosystem Veriti Thermal Cycler (Photo courtesy of Life Technologies).

High-Risk Female Groups Screened for Fabry Disease

Although measurement of lysosomal α-galactosidase A in women is not accurate for the diagnosis of Fabry disease, determining the range of the enzyme activity presented by heterozygous females could become a valuable tool for minimizing the burden of screening by DNA sequencing all potential carriers.   More...
26 Jun 2014
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Noninvasive Test Identifies Childhood Metabolic Disease Risk

Salivary biomarkers have been used as a tool for identifying children who are at risk for developing Type 2 diabetes.  More...
25 Jun 2014
Image:  A photomicrograph of a paraganglioma, a carotid body tumor (Photo courtesy of Nephron).

Rare Adrenal Tumors Diagnoses Require Blood and Urine Testing

Clinical Practice Guideline for the diagnosis and treatment of two types of rare adrenal tumors, pheochromocytomas and paragangliomas, has been issued.  More...
24 Jun 2014
Image: A linear ion trap combined with a Fourier transform ion cyclotron resonance (LTQ-FT) mass spectrometer (Photo courtesy of Thermo Scientific).

Humans May Benefit from Canine Bladder Cancer Assay

A unique group of proteins have been identified that indicate the presence of transitional cell carcinoma, the most common cause of bladder cancer and may lead to a new assay which could better diagnose this disease in both dogs and humans.   More...
23 Jun 2014
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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