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BioResearch

Image: HDL can remove cholesterol from arteries and shuttle it to the liver where it is eliminated, but this process can be disrupted in certain circumstances (such as deficiency of SCARB1) (Photo courtesy of Dr. Daniel Rader, University of Pennsylvania).

Rare Mutation Increases Both HDL-Cholesterol and Heart Disease Risk

Increased risk of atherosclerosis has been attributed to a rare mutation in the gene that encodes the major liver cell receptor for HDL.  More...
20 Mar 2016
Image: Human beta cells grown in culture (blue). Cells on right were induced to undergo senescence, causing them to secrete more insulin, stained in red (Photo courtesy of Dr. Ronny Helman, the Hebrew University of Jerusalem).

Insulin Secretion Enhanced by Beta Cell Senescence

Cellular senescence, a condition of permanent cell cycle arrest that is considered a safeguard mechanism preventing aged or abnormal cells from further expansion, has been found to increase the insulin-producing capability of pancreatic beta cells.  More...
16 Mar 2016
Image: Mode of action of the dual cyclin kinase inhibitor ON123300 (Photo courtesy of Onconova Therapeutics).

Dual Cyclin-Dependent Kinase Inhibitor Effective Against Multiple Myeloma in Preclinical Studies

Results obtained during preclinical studies support the continued development of a dual cyclin-dependent kinase inhibitor for the treatment of multiple myeloma.  More...
16 Mar 2016
Image: Representation of the crystal structure of a CRISPR-associated protein (Photo courtesy of Wikimedia Commons).

Some CRISPR Gene Editing Complexes Target RNA

A team of molecular microbiologists have demonstrated that in some bacteria the CRISPR/Cas genome editing complex can edit RNA as well as DNA.  More...
15 Mar 2016
Image: Transmission electron micrograph (TEM) of Zika virus. Virus particles are 40 nanometers in diameter, with an outer envelope, and an inner dense core. The arrow points to a single virus particle (Photo courtesy of the CDC - US Centers for Disease Control and Prevention).

Growth of Zika virus in Brain Stem Cells Implies Involvement in Microcephaly

Experiments conducted in cultured human embryonic cortical neural progenitor cells have demonstrated that these cells are readily infected by the Zika virus, which induces the cells to produce new Zika virus particles while disrupting normal cell metabolism in a fashion that eventually kills the cells.  More...
15 Mar 2016
Image: The naked HIV capsid, left, would be quickly detected and eliminated from the cell, but a host protein, cyclophilin A, in red in the image on the right, binds to the capsid and enables it to transit through the cell undetected (Photo courtesy of Dr. Juan Perilla, University of Illinois).

HIV Binding Simulations Reveal How the Virus Invades the Host Cell Nucleus

A team of molecular virologists has combined advanced cryoelectron microscopy with the processing power of two supercomputers to develop a model that explains how HIV interacts with the host cell factor cyclophilin A to invade the nucleus of human cells.  More...
14 Mar 2016
Image: Mouse spleens that were infiltrated by TAL-1-positive T-ALL leukemia cells taken from human patients, with leukemia cells shown in brown. Images on the right are from mice treated with GSK-J4, while the mice on the left were not treated with the compound (Photo courtesy of Dr. Aissa Benyoucef, Ottawa Hospital Research Institute).

Experimental Drug Blocks Leukemia Growth in Mouse Model System

An experimental drug that blocks the activity of a specific histone demethylase enzyme was found to cure the TAL-1 form of acute T-cell lymphoblastic leukemia in a mouse model system.  More...
14 Mar 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.

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